Reproductive Toxicology, October 2016
Jerrold J. Heindel a , Bruce Blumberg b , Mathew Cave c , Ronit Machtinger d , Alberto Mantovani e , Michelle A. Mendez f , Angel Nadal g , Paola Palanza h , Giancarlo Panzica i , Robert Sargis j , Laura N. Vandenberg k , Frederick vom Saal l
The recent epidemics of metabolic diseases, obesity, type 2 diabetes(T2D), liver lipid disorders and metabolic syndrome have largely been attributed to genetic background and changes in diet, exercise and aging. However, there is now considerable evidence that other environmental factors may contribute to the rapid increase in the incidence of these metabolic diseases.
This review will examine changes to the incidence of obesity, T2D and non-alcoholic fatty liver disease (NAFLD), the contribution of genetics to these disorders and describe the role of the endocrine system in these metabolic disorders. It will then specifically focus on the role of endocrine disrupting chemicals (EDCs) in the etiology of obesity, T2D and NAFLD while finally integrating the information on EDCs on multiple metabolic disorders that could lead to metabolic syndrome.
We will specifically examine evidence linking EDC exposures during critical periods of development with metabolic diseases that manifest later in life and across generations.
endocrine disruptors; obesogens; metabolism disruptors; developmental origins of health and disease; obesity; diabetes; lipid disorders
National Institute of Environmental Health Sciences, Division of Extramural Research and Training Research Triangle Park, NC, USA
University of California, Department of Developmental and Cell Biology, Irvine CA, USA
University of Louisville, Division of Gastroenterology, Hepatology and Nutrition, Louisville KY, USA
Sheba Medical Center and Tel Aviv University, Tel Aviv, Israel
Instituto Superiore di Sanita, Rome, Italy
University of North Carolina at Chapel Hill, School of Public Health, Chapel Hill NC, USA
Institute of Bioengineering and CIBERDEM, Miguel Hernandez University of Elche, Elche, Alicante, Spain
University of Parma, Department of Neurosciences, Parma, Italy
University of Turin, Department of Neuroscience and Neuroscience Institute Cavalieri Ottolenghi (NICO), Turin, Italy
University of Chicago, Section of Endocrinology, Diabetes and Metabolism, Department of Medicine, Chicago, IL, USA
University of Massachusetts, Department of Environmental Health Sciences, School of Public Health & Health Sciences, Amherst MA, USA
University of Missouri, Department of Biological Sciences, Columbia, MO, USA
Events & Meetings
Our young researchers present their work to collegues. From January to December, every two weeks, on friday at 2:00 pm
Seminars Room, NICO