Turin, Italy | 8 – 9 November 2024
III edition – hybrid workshop
MOTOR NEURON DISEASES
UNDERSTANDING THE PATHOGENETIC MECHANISMS TO DEVELOP THERAPIES
The meeting, organized within the NODES project, is in line with the research and innovation program ”Health Industry and Silver Economy” (Spoke5), providing knowledge on innovative diagnostic/therapeutic strategies and regenerative medicine.
Organizers: prof. Marina Boido & Serena Stanga
The meeting in numbers:
10 confirmed speakears
2 sessions of selected talks of participants
2 poster sessions
4 awards for the best presentations and posters
1 social dinner
VENUES Palace of the Anatomical Institutes, C.so Massimo D’Azeglio 52, 10124, Torino, Italy
The third edition of the hybrid workshop will focus on:
- the most recent cellular and molecular mechanisms involved in the pathogenesis and progression of neuromuscular diseases (as ALS, SMA…) and, more in general, of pathologies characterized by muscular atrophy
- currently available treatments and new developing therapeutic strategies
- practical activities for advanced imaging methods and in silico analysis of muscle innervation
SCIENTIFIC PROGRAM
download pdf
Session I – SMA disease mechanisms and therapeutic approaches
Melissa Bowerman, UK – Considering the importance of peripheral metabolic defects in the progression of neurodegenerative diseases: a focus on SMA
George Mentis, USA – Sensory dysfunction as a major pathogenic event in mouse models and patients with spinal muscular atrophy
Piera Smeriglio, France – Epigenetic alterations in SMA
Session II – SMA: a look at the clinical research
Federica Ricci, Italy – The backward reasoning: inputs from SMA clinical practice
Marika Pane, Italy – The backward reasoning: inputs from SMA clinical evidence
Session III – ALS pathogenetic mechanisms
Eran Perlson, Israel – Unlocking ALS: Muscle Exosome Control TDP-43 Local Synthesis at the NMJ
Alain Prochiantz, France – From Parkinson Disease to Amyotrophic Lateral Sclerosis following the ENGRAILED-1 thread
Session IV – ALS heterogeneity and treatments
Cristina Moglia, Italy – ALS phenotype heterogeneity: not only motor symptoms
Letizia Mazzini, Italy – Innovative treatments for ALS: current state and future directions
PRACTICAL ACTIVITY
how to analyze the morphology and innervation of neuromuscular junctions, by image analysis software
Samuele Negro (Italy)
Roberta Schellino (Italy)
Closing Lecture
Clive Svendsen, USA – Using iPSC technology and bioengineering to treat and model motor neuron diseases
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Credits (CFU): 2 for attendance + 0.5 for poster presentation
REGISTRATION FEES
– In person attendance (including lectures, possibility to present a poster/oral presentation, practical activities, coffee breaks, light lunch AND social dinner): 130 €
– In person attendance (including lectures, possibility to present a poster/oral presentation, practical activities, coffee breaks/light lunch, NO social dinner): 90 €
– Online attendance (including lectures): 60 €
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