Our research focuses on the role of glia and progenitor cells in brain plasticity and repair , and on the implementation of cell replacement approaches and/or training protocols to promote functional recovery in CNS diseases.
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The adult central nervous system has only a limited capacity to repair itself spontaneously after trauma, stroke, or neurodegenerative disease. To identify new strategies that can improve recovery from functional deficits, we study how the brain develops, remodels through experience, and responds to injury.
Our research focuses on circuit plasticity and on the pivotal roles of astrocytes and oligodendrocytes, using both preclinical models and human cells derived from pluripotent stem cells.
From basic science to translational approaches, we develop strategies centered on cell replacement and circuit reconstruction, with the goal of promoting functional recovery in neurodevelopmental and neurodegenerative disorders.
The group is organized into three thematic units and includes faculty, postdocs, PhD students, and Master’s and Bachelor’s students. We work in close integration, fostering strong exchange between cellular biology, human in vitro models, and preclinical studies.
Circuit Reconstruction and Cell Replacement
Project Leader: A. Buffo
We harness cellular plasticity and human pluripotent stem cell-derived cell products and models to replace degenerated neurons and promote functional integration of neural grafts. Our goal is to rebuild circuits that restore lost functions, with a particular focus on models of neurodegenerative diseases such as Huntington’s disease.
Astrocyte Diversity and Functions
Project Leaders: V. Cerrato and A. Buffo
We investigate how astrocyte subtypes diversify and how they contribute to development, injury response, and regeneration. By dissecting the signals that drive the acquisition of pro-repair properties, we aim to identify novel therapeutic targets.
Oligodendrocyte Biology and Pathology
Project Leader: E. Boda
We study progenitors and myelinating oligodendrocytes, focusing on the factors that regulate their function and myelin deposition. Our aim is to enhance protective and reparative mechanisms in pathological conditions such as microcephaly, leukodystrophies, and multiple sclerosis. We are also interested in myelin plasticity and its role in regulating behavior and memory formation.
