Physiopathology of neural stem cells

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Group leader:  Annalisa Buffo 

Physiopathology of neural stem cells

Pubblicazioni

2021

Furlan C, Montarolo F, Di Gregorio E, Parolisi R, Atlante S, Buffo A, Bertolotto A, Aime S, Gianolio E.J  Analysis of the Gadolinium retention in the Experimental Autoimmune Encephalomyelitis (EAE) murine model of Multiple Sclerosis.   Trace Elem Med Biol. 2021 Aug 2;68:126831. doi: 10.1016/j.jtemb.2021.126831. Online ahead of print. PMID: 34364067

Eriola Hoxha, Ilaria Balbo, Roberta Parolisi, Matteo Audano, Francesca Montarolo, Francesco Ravera, Michela Guglielmotto, Luisa Muratori, Stefania Raimondo, Eleonora Di Gregorio, Annalisa Buffo, Alfredo Brusco, Barbara Borroni, Nico Mitro, Donatella Caruso, Filippo Tempia (2021)  Elovl5 is required for proper action potential conduction along peripheral myelinated fibers.  Glia. 17 June 2021  https://doi.org/10.1002/glia.24048  

Ilaria Balbo, Francesca Montarolo, Enrica Boda, Filippo Tempia and Eriola Hoxha (2021)  Elovl5 Expression in the Central Nervous System of the Adult Mouse.   Front. Neuroanat., 29 April 2021  doi.org/10.3389/fnana.2021.669073

Lorenzati M, Boda E, Parolisi R, Bonato M, Borsello T, Herdegen T, Buffo A*, Vercelli A*.  c‐Jun N‐terminal kinase 1 (JNK1) modulates oligodendrocyte progenitor cell architecture, proliferation and myelination.  Sci Rep 2021 11:7264. *co-last authors

Kantzer CG#, Parmigiani E#, Cerrato V, Tomiuk S, Knauel M, Jungblut M, Buffo A*, Bosio A*.  ACSA-2 and GLAST classify subpopulations of multipotent and glial restricted cerebellar precursors . J Neurosci Res 2021 May 31. doi: 10.1002/jnr.24842  
Christina Geraldine Kantzer and Elena Parmigiani contributed equally to this work

Parolisi R, Montarolo F, Pini A, Rovelli S, Cattaneo A, Bertolotto A, Buffo A, Bollati V, Boda E.  Exposure to fine particulate matter (PM 2.5 ) hampers myelin repair in a mouse model of white matter demyelination.  Neurochem Int. 2021 Feb 12;145:104991. doi: 10.1016/j.neuint.2021.104991. Online ahead of print.PMID: 33587955

Nato G, Corti A, Parmigiani E, Jachetti E, Lecis D, Colombo MP, Delia D, Buffo A*, Magrassi*L.   Immune-tolerance to human iPS-derived neural progenitors xenografted into the immature cerebellum is overridden by species-specific differences in differentiation timing.   Sci Rep. 2021 Jan 12;11(1):651. doi: 10.1038/s41598-020-79502-9.PMID: 33436685  Free PMC article.
*co-last authors

Vigo T, Voulgari-Kokota A, Errede M, Girolamo F, Ortolan J, Mariani MC, Ferrara G, Virgintino D, Buffo A, Kerlero de Rosbo N, Uccelli A.Glia  Mesenchymal stem cells instruct a beneficial phenotype in reactive astrocytes.  2021 May;69(5):1204-1215. doi: 10.1002/glia.23958. Epub 2020 Dec 31.PMID: 33381863

2020

Vigo T, Voulgari-Kokota A, Errede M, Girolamo F, Ortolan J, Mariani MC, Ferrara G, Virgintino D, Buffo A, Kerlero de Rosbo N, Uccelli A. (2020)  Mesenchymal stem cells instruct a beneficial phenotype in reactive astrocytes.   Glia. Dec 31. doi: 10.1002/glia.23958.

Staurenghi E, Cerrato V, Gamba P, Testa G, Giannelli S, Leoni V, Caccia C, Buffo A, Noble W, Perez-Nievas BG, Leonarduzzi G. (2020)  Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2.  Redox Biol. 39:101837. doi: 10.1016/j.redox.2020.101837.

Giorgio E, Pesce E, Pozzi E, Sondo E, Ferrero M, Morerio C, Borrelli G, Della Sala E, Lorenzati M, Cortelli P, Buffo A, Pedemonte N, Brusco A. (2020)  A high-content drug screening strategy to identify protein level modulators for genetic diseases: a proof-of-principle in Autosomal Dominant LeukoDystrophy (ADLD).  Hum Mutat. Nov 30. doi: 10.1002/humu.24147.

Besusso D*#, Schellino R#, Boido M, Belloli S, Parolisi R, Conforti P, Faedo A, Cernigoj M, Campus I, Laporta A, Dickinson Bocchi V, Murtaj V, Parmar M, Spaiardi P, Talpo F, Maniezzi C, Toselli MG, Biella G, Moresco RM, Vercelli A, Buffo A* and Cattaneo E*.(2020)  Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease.   Stem Cell Reports. 2020 Apr 8. pii: S2213-6711(20)30108-9. doi:10.1016/j.stemcr.2020.03.018.
*corresponding authors; #co-first authors.

Buffo A, Ceruti S. (2020)  Editorial overview: Modulation of neurogenesis.  Curr Opin Pharmacol. 50:96-99. doi: 10.1016/j.coph.2020.03.001.

Carulli D, Broersen R, de Winter F, et al.  Cerebellar plasticity and associative memories are controlled by perineuronal nets  [published online ahead of print, 2020 Mar 9].  Proc Natl Acad Sci U S A . 2020;201916163. doi:10.1073/pnas.1916163117

Marangon D, Boda E, Parolisi R, Negri C, Giorgi C, Montarolo F, Perga S, Bertolotto A, Buffo A, Abbracchio MP, Lecca D (2020)  In vivo silencing of miR‐125a‐3p promotes myelin repair in models of white matter demyelination.  Glia. First published:12 March 2020  https://doi.org/10.1002/glia.23819

Mitoma H, Buffo A, Gelfo F, Guell X, Fucà E, Kakei S, Lee J, Manto M, Petrosini L, Shaikh AG, Schmahmann JD. (2020)  Consensus Paper.   Cerebellar Reserve: From Cerebellar Physiology to Cerebellar Disorders.   Cerebellum. 19(1):131-153. doi: 10.1007/s12311-019-01091-9.

Becerra-González M, Varman Durairaj R, Ostos Valverde A, Gualda EJ, Loza-Alvarez P, Portillo Martínez W, Gómez-González GB, Buffo A, Martínez-Torres A. (2020)  Response to Hypoxic Preconditioning of Glial Cells from the Roof of the Fourth Ventricle.  Neuroscience. 439:211-229. doi: 10.1016/j.neuroscience.2019.09.015.

Finetti F, Schiavo I, Ercoli J, Zotta A, Boda E, Retta SF, Trabalzini L. (2020)  KRIT1 loss-mediated upregulation of NOX1 in stromal cells promotes paracrine pro-angiogenic responses.  Cell Signal. 68:109527. doi: 10.1016/j.cellsig.2020.109527.

Boda E, Rigamonti AE, Bollati V (2020)  Understanding the effects of air pollution on neurogenesis and gliogenesis in the growing and adult brain.  Curr Opin Pharmacol, 50:61-66.  doi: 10.1016/j.coph.2019.12.003.

Finetti F, Schiavo I, Ercoli J, Zotta A, Boda E, Retta SF, Trabalzini L (2020)  KRIT1 loss-mediated upregulation of NOX1 in stromal cells promotes paracrine proangiogenic responses.  Cell Signal. 2020 Jan 6:109527. doi: 10.1016/j.cellsig.2020.109527      

Cerrato V (2020)  Cerebellar Astrocytes: Much More Than Passive Bystanders In Ataxia Pathophysiology.   J. Clin. Med. 9(3), 757;  https://doi.org/10.3390/jcm9030757

Fornasari BE, El Soury M, Nato G, Fucini A, Carta G, Ronchi G, Crosio A, Perroteau I, Geuna S, Raimondo S, Gambarotta G. (2020).  Fibroblasts Colonizing Nerve Conduits Express High Levels of Soluble Neuregulin1, a Factor Promoting Schwann Cell Dedifferentiation.  Cells. 1;9(6):1366. doi: 10.3390/cells9061366.

2019

Salvi M, Cerrato V, Buffo A, Molinari F. Automated segmentation of brain cells for clonal analyses in fluorescence microscopy images (2019). J Neurosci Methods. 325:108348. doi: 10.1016/j.jneumeth.2019.108348.

Giorgio E, Lorenzati M, Rivetti di Val Cervo P, Brussino A, Cernigoj M, Della Sala E, Bartoletti Stella A, Ferrero M, Caiazzo M, Capellari S, Cortelli P, Conti L, Cattaneo E, Buffo A, Brusco A.  Allele-specific silencing as treatment for gene duplication disorders: proof-of-principle in autosomal dominant leukodystrophy   (2019). Brain. 2019 May 29. pii: awz139. doi: 10.1093/brain/awz139.

Lombardi M, Parolisi R, Scaroni F, Bonfanti E, Gualerzi A, Gabrielli M, Kerlero de Rosbo N, Uccelli A, Giussani P, Viani P, Garlanda C, Abbracchio MP, Chaabane L, Buffo A, Fumagalli M, Verderio C. Detrimental and protective action of microglial extracellular vesicles on myelin lesions: astrocyte involvement in remyelination failure (2019). Acta Neuropathol. doi: 10.1007/s00401-019-02049-1.

Becerra-González M, Varman Durairaj R, Ostos Valverde A, Gualda EJ, Loza-Alvarez P, Portillo Martínez W, Berenice Gómez-González G, Buffo A, Martínez-Torres A. Response to Hypoxic Preconditioning of Glial Cells from the Roof of the Fourth Ventricle (2019). Neuroscience. pii: S0306-4522(19)30660-8. doi: 10.1016/j.neuroscience.2019.09.015.

Vieceli Dalla Sega, F., Mastrocola, R. Aquila, G., Fortini, F., Fornelli, C., Zotta, A., Cento, A.S., Perrelli, A., Boda, E., Pannuti, A., Marchi, S., Pinton, P., Ferrari, R., Rizzo, P., Retta, S.F. KRIT1 Deficiency Promotes Aortic Endothelial Dysfunction (2019). Int. J. Mol. Sci. 20, 4930. 

Boda E. Myelin and oligodendrocyte lineage cell dysfunctions: New players in the etiology and treatment of depression and stress-related disorders. (2019) Eur J Neurosci. 2019 Nov 17. doi: 10.1111/ejn.14621.

2018

Roberta Parolisi, Enrica Boda. NG2 Glia: Novel Roles beyond Re-/Myelination. (2018) Neuroglia 2018, 1(1), 151-175  

Cerrato V, Parmigiani E, Figueres-Oñate M, Betizeau M, Aprato J, Nanavaty I, Berchialla P, Luzzati F, de'Sperati C, López-Mascaraque L, Buffo A. Multiple origins and modularity in the spatiotemporal emergence of cerebellar astrocyt eheterogeneity (2018). PLoS Biol. 2018 Sep 27;16(9):e2005513. doi:10.1371/journal.pbio.2005513

Cerrato V, Mercurio S, Leto K, Fucà E, Hoxha E, Bottes E, Pagin M, Milanese M, Chew-Yee Ngan, Concina G, Ottolenghi S, Chia-Lin Wei, Bonanno G, Pavesi G, Tempia F, Buffo A and Nicolis KS.  Sox2 conditional mutation in mouse causes ataxic symptoms, cerebellar vermis hypoplasia, and postnatal defects of Bergmann glia   (2018) Glia . 2018 May 6. doi: 10.1002/glia.23448

Bertero A, Liska A, Pagani M, Parolisi R, Masferrer ME, Gritti M, Pedrazzoli M, Galbusera A, Sarica A, Cerasa A, Buffelli M, Tonini R, Buffo A, Gross C, Pasqualetti M, Gozzi A. Autism-associated 16p11.2 microdeletion impairs prefrontal functional connectivity in mouse and human. Brain. 2018 May 2. doi: 10.1093/brain/awy111.

Carulli D. Perineuronal Nets: A Mechanism to Control Brain Plasticity. The Scientist. April 1, 2018

Prada I, Gabrielli M, Turola E, Iorio A, D'Arrigo G, Parolisi R, De Luca M, Pacifici M, Bastoni M, Lombardi M, Legname G, Cojoc D, Buffo A, Furlan R, Peruzzi F, Verderio C. Glia-to-neuron transfer of miRNAs via extracellular vesicles: a new mechanism underlying inflammation-induced synaptic alterations. Acta Neuropathol. 2018 Apr;135(4):529-550. doi: 10.1007/s00401-017-1803-x. Epub 2018 Jan 4.

Parolisi R and Boda E.  NG2 Glia: Novel Roles beyond Re-/Myelination.  (2018). Neuroglia. 1(1), 151-175.

2017

Garello F, Pagoto A, Arena F, Buffo A, Blasi F, Alberti D, Terreno E. MRI visualization of neuroinflammation using VCAM-1 targeted paramagnetic micelles. Nanomedicine. 2017 Nov 8. pii: S1549-9634(17)30181-8. doi: 10.1016/j.nano.2017.10.002.

Boda E, Nato G, Buffo A. Emerging pharmacological approaches to promote neurogenesis from endogenous glial cells. Biochem Pharmacol. 2017 Oct 1;141:23-41. doi: 10.1016/j.bcp.2017.06.129.

Azzalin A, Nato G, Parmigiani E, Garello F, Buffo A, Magrassi L. Inhibitors of GLUT/SLC2A Enhance the Action of BCNU and Temozolomide against High-Grade Gliomas. Neoplasia. 2017 Apr;19(4):364-373. doi: 10.1016/j.neo.2017.02.009.

Kempf A, Boda E, Kwok JCF, Fritz R, Grande V, Kaelin AM, Ristic Z, Schmandke A, Schmandke A, Tews B, Fawcett JW, Pertz O, Buffo A , Schwab ME. Control of Cell Shape, Neurite Outgrowth, and Migration by a Nogo-A/HSPG Interaction. Dev Cell. 2017 Oct 9;43(1):24-34.e5. doi: 10.1016/j.devcel.2017.08.014. Epub 2017 Sep 21.

Fucà E, Guglielmotto M, Boda E, Rossi F, Leto K, Buffo A. Preventive motor training but not progenitor grafting ameliorates cerebellar ataxia and deregulated autophagy in tambaleante mice . Neurobiol Dis. 2017 Feb 22.

Faedo A, Laporta A, Segnali A, Galimberti M, Besusso D, Cesana E, Belloli S, Moresco RM, Tropiano M, Fucà E, Wild S, Bosio A, Vercelli AE, Biella G, Cattaneo E.   Differentiation of human telencephalic progenitor cells into MSNs by inducible expression of Gsx2 and Ebf1 . Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1234-E1242.

Joshi P, Gabrielli M, Ponzoni L, Pelucchi S, Stravalaci M, Beeg M, Mazzitelli S, Braida D, Sala M, Boda E, Buffo A, Gobbi M, Gardoni F, Matteoli M, Marcello E, Verderio C. Fingolimod Limits Acute Aβ Neurotoxicity and Promotes Synaptic Versus Extrasynaptic NMDA Receptor Functionality in Hippocampal Neurons. Sci Rep. 2017 Jan 30;7:41734. doi: 10.1038/srep41734

Parolisi R, Cozzi B, Bonfanti L (2017)  Non-neurogenic SVZ-like niche in dolphins, mammals devoid of olfaction.  Brain Struct Funct 222: 2625-2639.

2016

Pellegrino RM, Boda E, Montarolo F, Boero M, Mezzanotte M, Saglio G, Buffo A, Roetto A. Transferrin Receptor 2 Dependent Alterations of Brain Iron Metabolism Affect Anxiety Circuits in the Mouse. Sci Rep. 2016 Aug 1;6:30725. doi: 10.1038/srep30725.

Leto K, Arancillo M, Becker EBE, Buffo A, Chiang C, Ding B, Dobyns WB, Dusart I,  Haldipur P, Hatten ME, Hoshino M, Joyner AL, Kano M, Kilpatrick DL, Koibuchi N, Marino S, Martinez S, Millen KJ, Millner TO, Miyata T, Parmigiani E, Schilling K, Sekerková G, Sillitoe RV,  Sotelo S, Uesaka N, Wefers A, Wingate RJT, Hawkes R (2015)  Consensus Paper: Cerebellar Development . Cerebellum. PMID: 26439486

De Luca A, Cerrato V, Fucà E, Parmigiani E, Buffo A, Leto K (2015) Sonic hedgehog patterning during cerebellar development . Cellular and Molecular Life Sciences DOI: 10.1007/s00018-015-2065-1

2015

Cupolillo D, Hoxha E, Faralli A, De Luca A, Rossi F, Tempia F, Carulli D (2015) Autistic-like traits and cerebellar dysfunction in Purkinje cell  PTEN  knock-out mice . Neuropsychopharmacology

Parmigiani E, Leto K, Rolando C, Figueres-Oñate M, López-Mascaraque L, Buffo A, Rossi F (2015)  Heterogeneity and Bipotency of Astroglial-Like Cerebellar Progenitors along the Interneuron and Glial Lineages .  J Neurosci 35:7388-7402. 

De Luca A, Parmigiani E, Tosatto G, Martire S, Hoshino M, Buffo A, Leto K, Rossi F (2015) Exogenous Sonic hedgehog modulates the pool of GABAergic interneurons during cerebellar development . Cerebellum 14:72-85.

Nato G, Caramello A, Trova S, Avataneo V, Rolando C, Taylor V, Buffo A, Peretto P, Luzzati F (2015)  Striatal astrocytes produce neuroblasts in an excitotoxic model of Huntington's disease . Development 142:840-845. 

Boda E, Di Maria S, Rosa P, Taylor V, Abbracchio MP, Buffo A (2015) Early phenotypic asymmetry of sister oligodendrocyte progenitor cells after mitosis and its modulation by aging and extrinsic factors. Glia 63:271-286.

Vazquez-Sanroman D, Carbo-Gas M, Leto K, Cerezo-Garcia M, Gil-Miravet I, Sanchis-Segura C, Carulli D, Rossi F, Miquel M. (2015) Cocaine-induced plasticity in the cerebellum of sensitised mice . Psychopharmacology. PMID: 26482898

Oohashi T, Edamatsu M, Bekku Y, Carulli D. (2015) The hyaluronan and proteoglycan link proteins: Organizers of the brain extracellular matrix and key molecules for neuronal function and plasticity. Exp Neurol. pii: S0014-4886(15)30092-3. doi:10.1016/j.expneurol.2015.09.010. PMID: 26387938

Faralli A, Dagna F, Albera A, Bekku Y, Oohashi T, Albera R, Rossi F, Carulli D. (2015) Modifications of perineuronal nets and remodelling of excitatory and inhibitory afferents during vestibular compensation in the adult mouse . Brain Struct Funct. PMID: 26264050

Vazquez-Sanroman D, Leto K, Cerezo-Garcia M, Carbo-Gas M, Sanchis-Segura C, Carulli D, Rossi F, Miquel M. (2015) The cerebellum on cocaine: plasticity and metaplasticity . Addict Biol. 20:941-55.