Claudia Verderio, CNR Research director c/o Università di Milano – Bicocca, Italy
PI NICO Enrica Boda, Annalisa Buffo
The interplay between microglia and brain cells
We collaborate to investigatecell-to-cell communication in the diseased brain by providing models to study detrimental and beneficial effects of microglia, which is the focus of Claudia’s research.
Fernando de Castro Soubriet, Cajal Institute Madrid, Spain
NICO PI Martina Lorenzati, Annalisa Buffo
Role of mutated Anosmin-1 in cerebellar functions
Through the investigation of the impact of Anosmin-1 duplication in mouse mutants, we learn about how myelin modulates action potential conduction along PC axons, organizes the axon hillock and Ranvier nodes, and affects cerebellar functions.
Gerardo Biella, University of Pavia, Italy
PI NICO Annalisa Buffo
Functional integration of grafted neurons
By combining complementary skills, with Gerardo and his team we look into the therapeutic action of donor neurons grafted to replace degenerated host neurons. By bringing critical expertise, Gerardo and his team enable the investigation of the functional connectivity of human xenografts and rodent allografts.
Giorgia Quadrato, USC Stem Cell, LA, USA
PI NICO Annalisa Buffo
Optimization of human cerebellum organoids
Our research focuses on optimizing human cerebellar models to study physiology and disease. We aim to enhance their maturation, cytoarchitectural organization, and faithful cell type representation. To achieve this, we employ complementary approaches that converge on these goals.
Lorenzo Magrassi, University of Pavia, Pavia, Italy
Sergio Casas-Tinto, Instituto de Salud Carlos III, UAM, Madrid, Spain
Giulia Nato, Department of Life Sciences and Systems Biology, University of Turin, Torino, Italy
NICO PI Annalisa Buffo
Role of PTEN alterations in hamartomas
With these colleagues we study how hamartomas develop in the adult brain upon PTEN mutations in both vertebrate and invertebrate models.
Ludovic Telley, Université Claude Bernard Lyon 1, Melis UCBL, Lion, France
PI NICO Valentina Cerrato, Annalisa Buffo
Molecular mechanisms controlling astrocyte diversification
With Ludovic we synergize to investigate cerebellar development with single cell omics. We specifically ask how diverse astrocyte identities are established and maintained in both rodent and human systems.
Magdalena Goetz, Helmholtz Zentrum and LMU, Munich, Germany
PI NICO Annalisa Buffo
Heterogeneity, stem cell properties and reprogramming into neurons of astrocytes
This long-standing collaboration was reinforced within the recent Horizon 2020 Neural Stem Cell reconstruct grant. It focuses on the common interest on astrocyte properties, reactivity, and the mechanisms underlying- and potential exploitation of- the neural stem cell potential of these glial cells.
Marco Cambiaghi, University of Verona, Italy
PI NICO Enrica Boda
Effects of non-invasive brain stimulation on myelin repair and plasticity
By combining complementary expertise, we are collaborating with Marco and his team to elucidate how brain activity modulation through non-invasive techniques may influence myelination in the healthy and diseased brain. Thanks to Marco’s expertise in in vivo electrophysiology, we are also investigating functional connectivity in behavior-relevant brain regions in mouse models of dysmyelination.
