Dr. Franziska Rother, MDC Berlin, Berlin, GERMANY
Sex-age differences in importin alpha3 ko mice
Rita Levi Montalcini Grant/ D34Health
PI NICO Letizia Marvaldi
We are elucidating if importin alpha3 protein is involved in sex-age differences in sensory neurons. We are studying on the Behavioral level (in collaboration With Franziska Rother) and on the cell-molecular mechanism at the NICO.
Prof. Michaela Kress, Medical University Innsbruck, Innsbruck, AUSTRIA
PI NICO Letizia Marvaldi
Establishment iPSCs sensory neurons at NICO
Rita Levi Montalcini Grant, UNFOLD, D34Health
This project is based on establishing iPSC-derived sensory neurons at NICO to support several upcoming projects, including the investigation of neuropathic pain signaling in vitro. It also aims to develop a method for studying multiple sclerosis (MS) in vitro using co-cultures of sensory neurons and glial cells with other NICO PIs Annalisa Buffo and Stefania Raimondo.
Pascal Kienlen-Campard, Institute of Neuroscience (IoNS), Université catholique de Louvain (UCLouvain), Bruxelles, Belgium
PI NICO Serena Stanga
Early mechanisms in Alzheimer’s disease
The project aims to discover Amyloid Precursor Protein (APP) and Presenilins (PSs) physiopathological function to understand the molecular mechanisms recruited by APP and PSs in the early phases of Alzheimer’s disease (AD).
Clive Svendsen, Regenerative Medicine Institute, Cedars Sinai, Los Angeles, California (USA)
PI NICO Serena Stanga
A role for dysfunctional mitochondria in ALS
IBRO Collaborative Research Grant program, MUR-Next Generation EU-PRIN2022
The project aims to improve the knowledge of pathological mechanisms related to mitochondria dysfunctions to facilitate the recognition of early disease manifestations and ultimately identify new therapies for Amyotrophic Lateral Sclerosis (ALS).
Valeria Valsecchi, Università degli studi di Napoli, Federico II, Napoli, Italia
PI NICO Serena Stanga
Targeting mACONITASE and KIF5A to rescue mitochondrial mobility and function for the treatment of motor neuron diseases
MUR-Next Generation EU-PRIN2022
The project aims at understanding the mechanisms underpinning mitochondria altered function and trafficking along motor neurons in Spinal Muscular Atrophy (SMA) and Amyotrophic Lateral Sclerosis (ALS) diseases, at discovering new targets and new potential therapeutic approaches against neurodegeneration.
Ruben Artero, University Institute of Biotechnology and Biomedicine, Univ. València, Spain;
Cecile Martinat, INSERM, Université Paris Saclay, I-STEM, AFM-Telethon, Corbeil-Essonnes, France
PI NICO: Marina Boido
Uncovering the mechanism of action and synergistic potential of a SMA repositioned therapy
SMA EUROPE
We are investigating the efficacy of GT5 (code name), a repurposed drug capable of increasing the production of SMN, the protein missing in Spinal Muscular Atrophy.
Elia Di Schiavi, CNR Institute of Biosciences and BioResources, Naples
Piera Smeriglio, INSERM, Université Paris Saclay
PI NICO Marina Boido
A combinatorial pharmacotherapeutic approach to counteract Spinal Muscular Atrophy
AFM Telethon
We are exploiting the drug repositioning approach to identify new SMN-independent molecules for the treatment of Spinal Muscular Atrophy.
Rico Schieweck, Univ, Luxembourg;
Gabriella Viero, CNR, Trento
PI NICO Marina Boido
Rebalancing the epitranscriptional landscape as an advanced therapy in SMA
CURE SMA
The project aims to elucidate the impact of SMN on RNA methylation to pave the way for novel combinatorial therapies.
Michela Rigoni, Department of Biomedical Sciences, University of Padua, Padua, Italy
PI NICO Roberta Schellino, Marina Boido
Targeting Neuromuscular Junction Regeneration as a Therapeutic Strategy in ALS
The project aims to find novel molecular targets to promote motor neuron survival and to reduce/ slow down the degeneration of motor axon terminals in ALS disease.
