Neuron-Astroglia Cell Fate Decision in the Adult Mouse Hippocampal Neurogenic Niche Is Cell-Intrinsically Controlled by COUP-TFI In Vivo

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13/07/2018
Neuron-Astroglia Cell Fate Decision in the Adult Mouse Hippocampal Neurogenic Niche Is Cell-Intrinsically Controlled by COUP-TFI In Vivo

Cell Reports , 10 July 2018
Neuron-Astroglia Cell Fate Decision in the Adult Mouse Hippocampal Neurogenic Niche Is Cell-Intrinsically Controlled by COUP-TFI In Vivo

Sara Bonzano 1,2,3 , Isabella Crisci 1,2 , Anna Podlesny-Drabiniok 4 , Chiara Rolando 5 , Wojciech Krezel 4 , Michèle Studer 3 , Silvia De Marchis 1,2

In the dentate gyrus (DG) of the mouse hippocampus, neurogenesis and astrogliogenesis persist throughout life. Adult-born neurons and astrocytes originate from multipotent neural stem cells (NSCs) whose activity is tightly regulated within the neurogenic niche. However, the cell-intrinsic mechanisms controlling neuron-glia NSC fate choice are largely unknown. Here, we show COUP-TFI/NR2F1 expression in DG NSCs and its downregulation upon neuroinflammation.

By using in vivo inducible knockout lines, a retroviral-based loss-of-function approach and genetic fate mapping, we demonstrate that COUP-TFI inactivation in adult NSCs and/or mitotic progenitors reduces neurogenesis and increases astrocyte production without depleting the NSC pool. Moreover, forced COUP-TFI expression in adult NSCs/progenitors decreases DG astrogliogenesis and rescues the neuro-astrogliogenic imbalance under neuroinflammation. Thus, COUP-TFI is necessary and sufficient to promote neurogenesis by suppressing astrogliogenesis.

Our data propose COUP-TFI as a central regulator of the neuron-astroglia cell fate decision and a key modulator during neuroinflammation in the adult hippocampus.

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1 Neuroscience Institute Cavalieri Ottolenghi (NICO), University of Turin, Orbassano 10043, Italy;
2 Department of Life Sciences and Systems Biology, University of Turin, Turin 10123, Italy;
3 Université Côte d’Azur (UCA) CNRS, Inserm, iBV, Nice 06108, France;
4 Institut de Génétique et de Biologie Moléculaire et Cellulaire; Inserm, U1258, CNRS, UMR 7104,   
  Université de Strasbourg France Illkirch 67404;
5 Department of Biomedicine, University of Basel, Basel 4031, Switzerland.

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