M. Fumagalli, University of Milan

Share on
Event date: 16/04/2015
milano_torino_2

Friday, April 17th 2015   - h. 14:00
Seminars Room, NICO
Extrinsic mechanisms regulate the GPR17 receptor during oligodendrocyte precursor cell maturation:  implications for the development of new remyelinating strategies

Marta Fumagalli
Laboratory of Molecular and Cellular Pharmacology of Purinergic Transmission
Department of Pharmacological and Biomolecular Sciences, University of Milan

During oligodendrocyte precursor cell differentiation, defective control of the membrane receptor GPR17 has been suggested to block cell maturation and impair remyelination under demyelinating conditions.

Here, we show that the ubiquitin ligase Mdm2, known to be involved in ubiquitination/degradation of p53, regulates GPR17 responses at the cell membrane by intertwining mTOR with G-protein receptor kinase 2.

Host:  Alessandro Vercelli

download pdf

Events & Meetings

08 november 2024

8-9 November :: Motor Neuron Diseases - III edition

Hybrid workshop  

REGISTRATION: from 2 nd  to 22 nd  of September 2024