NICO Progress Report
INN Open Neuroscience Forum 2018
From February to December, every two weeks, on friday at 2:00 pm
Seminars Room, NICO
vednesday 31 October - h 14:00
Simona Perga (Group Bertolotto)
The anti-inflammatory enzyme A20 the brain tissues of Multiple Sclerosis patients
Agenda 2018
19 October
Mattia Ghigo (Group Eva)
The long lasting effect of early life stress in mPFC. Perineuronal nets expression in a gene/environment interaction murine model
21 September
Marco Fogli (Group Buffo-Luzzati)
Dynamics of striatal astrocytes neurogenic activation and functional properties of their neuronal progeny
7 September
Gianmarco Pallavicini (Group Di Cunto)
Does KBP (KIAA1279) control midbody microtubule stability likewise CIT?
20 July
Chiara La Rosa (Group Bonfanti - Peretto)
CORTICAL LAYER II IMMATURE NEURONS ARE HETEROGENEOUS IN MAMMALS
The doublecortin-positive (DCX+) pre-natally generated neurons discovered in the layer II of the rodent piriform cortex are considered a reservoir of “immature” neurons in the adult brain. In some non-rodent species they extend into neocortex and in sheep also into subcortical regions. Hence, immature neurons might be more important in large-brained, long-living mammals. We assessed the occurrence, distribution and amount (linear density - cells/mm of layer II) of type 1 (small-bipolar) and type 2 (large-ramified) DCX+ cortical neurons at 4 comparable brain levels in 13 mammalian species endowed with different brain anatomy, lifespan, ecological niche. Sections were immunostained for cell proliferation (Ki-67, BrdU) and immaturity/maturity markers (PSA-NCAM, NeuN). All non-rodent species considered hosted DCX+ neurons in neocortex, with highly heterogeneous linear densities. By contrast, morphological and phenotypic features were rather constant: type 2 cells represented 10-20% of the total, mostly expressing NeuN, whereas 15-30% of DCX+ cells were also PSA-NCAM+. BrdU and Ki-67 antigen detection confirmed that all DCX+ neurons were non-newly generated/not proliferating. These results show that “immature” cortical neurons do represent a well preserved, yet, highly heterogeneous feature in mammals, especially considering rodent and non-rodent species.
6 July
Roberta Parolisi (Group Buffo)
Characterization of the action of extracellular vesicles derived from microglia on OPCs
EVs, being spontaneously produced by cells and containing a heterogeneous range of molecules, are emerging key mediators of intercellular communication.
We are studying the role of these vesicles released from alternatively activated microglia, on in vitro OPC proliferation and differentiation, and in vivo re-myelination after toxic demyelination
22 June
Marina Boido (Group Vercelli)
Unraveling the role of Nurr1 in a murine model of Amyotrophic Lateral Sclerosis
8 June
Giulia Nato (Group Buffo)
25th May
Valentina Cerrato (Group Buffo)
Clonal analysis: things you should know before going into it
10th May
Gaia Berto (Group Di Cunto)
TTC3: a Down Syndrome gene
involved in neuronal migration
Down syndrome (DS) is caused by trisomy of Human Chromosome 21 (HSA21). The clinical manifestations of DS vary in both penetrance and intensity among affected individuals, but the only hallmark common to all patients is intellectual disability (ID). DS-associated ID is the result of developmental brain abnormalities, leading to altered neuronal migration and connections within the cortex. One likely candidate for these phenotypes is TTC3, a HSA21 protein, whose expression is increased in cells derived from DS experimental models and from DS patients. Moreover, up-regulation of TTC3 inhibits neuronal differentiation by modulating actin cytoskeleton.
In this last years, we are studying the effect of TTC3 over-dosage in cortical development, up-regulating the protein using in utero electroporation and we demonstrated that TTC3 levels are critical for correct neuronal positioning within the cortex. These data support the hypothesis that DS-cortical phenotypes can be ascribed to the increased dosage of TTC3.
27th April
Eriola Hoxha (Group Tempia)
Role of Elovl5 for proper neuronal function
5th April
Ilaria Bertocchi (Group Eva)
A possible link between NPY-Y1R transmission and the expression of neuronal plasticity inhibitors in the limbic system
16th March
Francesca Montarolo (Gruppo Bertolotto)
Nuclear Receptor 4 A subfamily (NR4As) in Multiple Sclerosis patients: from blood to central nervous system
16th February
Isabella Crisci (Group De Marchis)
The transcription factor COUP-TFI in the adult hippocampal neurogenesis
26th Genuary
Roberta Schellino (Group Vercelli)
Grafting human ES cells into a rat model of Huntington’s Disease
12th Genuary
Giovanna Ponti (Group Panzica)
Sexual dimorphic features in SVZ-OB system are permanently affected by early postnatal genistein treatment
Agenda 2017
22nd December
Gianmarco Pallavicini (Group Di Cunto)
Sexually dimorphic effect of the maternal separation on anorexic rats
15th December
Alice Farinetti (Group Panzica)
Sexually dimorphic effect of the maternal separation on anorexic rats
7th December
Simona Perga (Group Bertolotto)
The anti-inflammatory enzyme TNFAIP3/A20 in the pathogenesis of Multiple Sclerosis
17th November
Martina Lorenzati (Group Vercelli)
Axo-glial interplay in oligodendrocytes specification and myelination: role of JNK1
10th November - h 14:00
Marwa El Soury (Group Geuna)
Role played by Soluble NRG1 in immediate responses to peripheral nerve injury
3rd November
Ilaria Bertocchi (Group Eva)
Dynamic distribution of a fear memory engram
15th September
Giulia Nato (Group Buffo)
Uncovering the neurogenic potential of striatal astrocytes
1st September
A. Adelaide Chiotto (Group Di Cunto)
Cortical defects in a mouse model of Down syndrome: the role of TTC3 gene
10 February
Enrica Boda (Group Buffo)
Heterogeneity in the oligodendrocyte progenitor cell (OPC) pool: lessons from a microcephaly model
24 February
Rebecca Gabriele (Group Tempia)
Elovl5 -/- mice as a model of spinocerebellar ataxia
10 March
Federico Bianchi (Group Di Cunto)
Citron Kinase deficiency leads to chromosomal instability and TP53-sensitive microcephaly
24 March
Chiara La Rosa (Group Bonfanti)
Structural plasticity in the brain parenchyma of different mammals
7 April
Marina Boido (Group Vercelli)
From muscle to spinal cord: therapeutic approaches for Spinal Muscular Atrop
21 April
Roberta Parolisi (Group Buffo)
Microglia-derived extracellular vesicles regulate the proliferation and differentiation of oligodendrocyte precursor cells
5 May
Gaia Berto (Gruppo Di Cunto)
TTC3: a Down syndrome gene involved in neuronal migration.
19 May
Francesca Montarolo (Group Bertolotto)
Nuclear receptor related 1 protein (Nurr1) in attention deficit hyperactivity disorder (ADHD): searching for a disease murine model
01 June
Valentina Cerrato (Group Buffo)
Astrogliogenesis in the cerebellum results from progenitors with distinct fate potencies and proliferative behaviors
09 June
Sara Trova (Group Peretto)
The Olfactory System Physiological Plasticity underlying reproduction
16 June
Marilena Marraudino (Group Panzica)
Kisspeptin innervation of the Hypothalamic Paraventricular Nucleus: key for reproductive and metabolic control. Effects of postnatal exposure to Genistein
30 June
Matilde Ghibaudi (Group Vercelli)
miRNAs and biomimetic scaffolds as potential strategies in SCI
14 July
Roberta Schellino (Group Vercelli)
Pharmacological JNK-pathway inhibition reduces severity of Spinal Muscular Atrophy (SMA)
Marco Fogli (Gruppo Buffo-Luzzati)
Dynamics of striatal astrocytes neurogenic activation and functional properties of their neuronal progeny
Events & Meetings
