Sviluppo e patologia del cervello

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Gruppo guidato da Alessandro Vercelli

brain-development_vercelli

Pubblicazioni

2021

Al-Thelayaa K, Marco Agusa,∗, Nauman Ullah Gilala, Yin Yanga, Giovanni Pintoreb, Enrico Gobbettib, Corrado Calì, Pierre J. Magistrettid,e, William Mifsudf, Jens Schneidera, ∗InShaDe: Invariant Shape Descriptors for visual 2D and 3D cellular and nuclear shape analysis and classification Computers&Graphics, in press

Tamagno E, Guglielmotto M. ESTROGENS  STILL REPRESENT AN ATTRACTIVE THERAPEUTIC APPROACH FOR ALZHEIMER'S DISEASE. Neural Regeneration Research  2021, 16 in press

Cofano F, Di Perna G, Bozzaro M, Longo A, Marengo N, Zenga F, Zullo N, Cavalieri M, Damiani L, Boges DJ, Agus M, Garbossa D and Calì C (2021) Augmented Reality in Medical Practice: From Spine Surgery to Remote Assistance. Front. Surg. 8:657901.

Garello F*, Boido M*#, Miglietti M, Bitonto V, Zenzola M, Filippi M, Arena F, Consolino L, Ghibaudi M, Terreno T. Imaging of inflammation in Spinal Cord Injury: novel insights on the usage of PFC-based contrast agents. Accepted on Biomedicines. *co-first; #corresponding author

Ghibaudi M, Boido M, Green D, Signorino E, Berto GE, Pourshayesteh S, Singh A, Di Cunto F, Dalmay T, Vercelli A. miR-7b-3p Exerts a Dual Role After Spinal Cord Injury, by Supporting Plasticity and Neuroprotection at Cortical Level. Front. Mol. Biosci., 31 March 2021, https://doi.org/10.3389/fmolb.2021.618869

Lavorato A, Raimondo S, Boido M, Muratori L, Durante G, Cofano F, Vincitorio F, Petrone S, Titolo P, Tartara F, Vercelli A, Garbossa D. Mesenchymal Stem Cell Treatment Perspectives in Peripheral Nerve Regeneration: Systematic Review. Int J Mol Sci. 2021 Jan 8;22(2):572. doi: 10.3390/ijms22020572.

Lorenzati M, Boda E, Parolisi R, Bonato M, Borsello T, Herdegen T, Buffo A*, Vercelli A*. c‐Jun N‐terminal kinase 1 (JNK1) modulates oligodendrocyte progenitor cell architecture, proliferation and myelination. Sci Rep 2021 11:7264. *co-last authors

Nani A, Manuello J, Mancuso L, Liloia D, Costa T, Vercelli A, Duca S, Cauda F. The pathoconnectivity network analysis of the insular cortex: A morphometric fingerprinting. Neuroimage. 2021 Jan 15;225:117481. doi: 10.1016/j.neuroimage.2020.117481.

Petrelli F, Tamara Zehnder, Luca Pucci, Corrado Cali, Bianca Maria Bondiolotti, Alicia Molinero Perez, Glenn Dallerac, Nicole Déglon, Bruno Giros, Fulvio Magara, Lorenzo Magrassi, Jean-Pierre Mothet, Linda Simmler, Paola Bezzi Astrocytic VMAT2 in the developing prefrontal cortex is required for normal grooming behavior in mice. BioRxiv doi:https://doi.org/10.1101/2021.01.27.428434

Rainero I, Summers MJ, Monter M, Bazzani M, Giannouli E, Aumayr G, Burin D, Provero P, Vercelli AE; My-AHA Consortium. The My Active and Healthy Aging ICT platform prevents quality of life decline in older adults: a randomized controlled study. Age Ageing. 2021 Jan 22:afaa290. doi: 10.1093/ageing/afaa290.

2020

Agus M, Al-Thelaya K, Cali C, Boido MM, Yang Y, Pintore G, Gobbetti E, Schneider J. 2020 InShaDe: Invariant Shape Descriptors for Visual Analysis of Histology 2D Cellular and Nuclear Shapes. Eurographics Workshop on Visual Computing for Biology and Medicine (VCBM), 10.2312/vcbm.20201173

Besusso D*#, Schellino R#, Boido M, Belloli S, Parolisi R, Conforti P, Faedo A, Cernigoj M, Campus I, Laporta A, Dickinson Bocchi V, Murtaj V, Parmar M, Spaiardi P, Talpo F, Maniezzi C, Toselli MG, Biella G, Moresco RM, Vercelli A, Buffo A* and Cattaneo E*.(2020) Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease. Stem Cell Reports. 2020 Apr 8. pii: S2213-6711(20)30108-9. doi:10.1016/j.stemcr.2020.03.018.
*corresponding authors; #co-first authors.

Boges DJ, M Agus M, Magistretti PJ, Calì C. 2020 Forget About Electron Micrographs: A Novel Guide for Using 3D Models for Quantitative Analysis of Dense Reconstructions. Neuromethods, Volume Microscopy, 263-604.

Boges D, Agus M, Sicat R, Magistretti PJ, Hadwiger M, C Calì (2020). Virtual reality framework for editing and exploring medial axis representations of nanometric scale neural structures. Computers & Graphics, June 24, 2020. DOI 10.1016/j.cag.2020.05.024

Boido M, Butenko O, Filippo C, Schellino R, Vrijbloed WV, Fariello RG, Vercelli A. A new protein curbs the hypertrophic effect of myostatin inhibition, adding remarkable endurance to motor performance in mice. PLoS One. 2020;15(3):e0228653. Published 2020 Mar 11. doi:10.1371/journal.pone.0228653

Boido M, Schellino R, Vercelli A. Neuromuscular correlations: development, pathology and aging. Pages 169-189. Giornale della Accademia di Medicina di Torino 2019. Anno CLXXXII.

Ciminelli BM, Menduti G, Benussi L, Ghidoni R, Binetti G, Squitti R, Rongioletti M, Nica S, Novelletto A, Rossi L, Malaspina P. 2020 Polymorphic Genetic Markers of the GABA Catabolism Pathway in Alzheimer's Disease. J Alzheimers Dis.;77(1):301-311.

Contino S, Suelves N, Vrancx C, Vadukul MD, Payen VL, Stanga S, Bertrand L and Kienlen-Campard P. 2020 Presenilin-deficient neurons and astrocytes display normal mitochondrial phenotypes. Front. Neurosci.; December 14; doi: 10.3389/fnins.2020.586108

Guglielmotto M, Manassero G, Vasciaveo V, Venezia M, Tabaton M, Tamagno E. Estrogens Inhibit Amyloid-β-Mediated Paired Helical Filament-Like Conformation of Tau Through Antioxidant Activity and miRNA 218 Regulation in hTau Mice. J Alzheimers Dis. 2020;77(3):1339-1351. doi: 10.3233/JAD-200707.PMID: 32804095

Menduti G, Rasà DM, Stanga S, Boido M. 2020 Drug Screening and Drug Repositioning as Promising Therapeutic Approaches for Spinal Muscular Atrophy Treatment. Front Pharmacol. Nov 12;11:592234.

Menduti G, Vitaliti A, Capo CR, Lettieri-Barbato D, Aquilano K, Malaspina P, Rossi L. 2020 SSADH Variants Increase Susceptibility of U87 Cells to Mitochondrial Pro-Oxidant Insult. Int J Mol Sci. Jun 19;21(12):4374.

Naldi A, Provero P, Vercelli A, Bergui M, Mazzeo AT, Cantello R, Tondo G, Lochner P. 2020 Optic nerve sheath diameter asymmetry in healthy subjects and patients with intracranial hypertension. Neurol Sci. Feb;41(2):329-333.

Nuzzi R, Caselgrandi P, Vercelli A. 2020 Effect of Mesenchymal Stem Cell-Derived Exosomes on Retinal Injury: A Review of Current Findings. Stem Cells Int. Oct 5;2020:8883616.

Opsomer R, Contino S, Perrin F, Gualdani R, Tasiaux B, Doyen P, Vergouts M, Vrancx C, Doshina A, Pierrot N, Octave JN, Gailly P, Stanga S, Kienlen-Campard P. 2020 Amyloid Precursor Protein (APP) controls excitatory/inhibitory synaptic inputs by regulating the transcriptional activator Neuronal PAS Domain Protein 4 (NPAS4). eNeuro. May 28;7(3).

Roig-Puiggros S, Vigouroux RJ, Beckman D, Bocai NI, Chiou B, Davimes J, Gomez G, Grassi S, Hoque A, Karikari TK, Kiffer F, Lopez M, Lunghi G, Mazengenya P, Meier S, Olguín-Albuerne M, Oliveira MM, Paraíso-Luna J, Pradhan J, Radiske A, Ramos-Hryb AB, Ribeiro MC, Schellino R, Selles MC, Singh S, Theotokis P, Chédotal A. 2020 Construction and reconstruction of brain circuits: normal and pathological axon guidance. J Neurochem. Apr;153(1):10-32.

Sanna MD, Manassero G, Vercelli A, Herdegen T, Galeotti N. 2020 The isoform-specific functions of the c-Jun N-terminal kinase (JNK) in a mouse model of antiretroviral-induced painful peripheral neuropathy. Eur J Pharmacol. Aug 5;880:173161.

Schellino R, Boido M, Vercelli A. 2020 The Dual Nature of Onuf's Nucleus: Neuroanatomical Features and Peculiarities, in Health and Disease. Front Neuroanat. Sep 4;14:572013.

Stanga S, Boido M and Kienlen-Campard P. 2020 How to build and to protect the neuromuscular junction: the role of the Glial cell line-Derived Neurotrophic Factor. IJMS,; December 24;22(1):E136.

Stanga S, Caretto A, Boido M, Vercelli A. Mitochondrial Dysfunctions: A Red Thread across
Neurodegenerative Diseases. Int J Mol Sci. 2020 May 25;21(10):3719. doi: 10.3390/ijms21103719.

Valsecchi V*, Boido M*, Montarolo F, et al. The transcription factor Nurr1 is up-regulated in amyotrophic lateral sclerosis patients and SOD1-G93A mice [published online ahead of print, 2020 Mar 18]. Dis Model Mech. 2020;dmm.043513. doi:10.1242/dmm.043513 - *co-authors

Wyart E, Bindels LB, Mina E, Menga A, Stanga S, Porporato PE. 2020 Cachexia, a systemic disease beyond muscle atrophy. Int J Mol Sci. Nov 14;21(22):8592.

2019

Boido M, Ghibaudi M, Gentile P, Favaro E, Fusaro R, Tonda-Turo C. Chitosan-based hydrogel to support the paracrine activity of mesenchymal stem cells in spinal cord injury treatment. Sci Rep. 2019 Apr 25;9(1):6402.         

Cofano F*, Boido M*, Monticelli M, Zenga F, Ducati A, Vercelli A, Garbossa D. Mesenchymal Stem Cells for Spinal Cord Injury: Current Options, Limitations, and Future of Cell Therapy. Int J Mol Sci. 2019 May 31;20(11). pii: E2698.

Crociara P, Chieppa MN, Vallino Costassa E, Berrone E, Gallo M, Lo Faro M, Pintore MD, Iulini B, D'Angelo A, Perona G, Botter A, Formicola D, Rainoldi A, Paulis M, Vezzoni P, Meli F, Peverali FA, Bendotti C, Trolese MC, Pasetto L, Bonetto V, Lazzari G, Duchi R, Perota A, Lagutina I, Quadalti C, Gennero MS, Dezzutto D, Desiato R, Boido M, Ghibaudi M, Valentini MC, Caramelli M, Galli C, Casalone C, Corona C. Motor neurondegeneration, severe myopathy and TDP-43 increase in a transgenicpig model of SOD1-linked familiar ALS. Neurobiol Dis 2019 Apr;124:263-275.

Guglielmotto M, Repetto IE, Monteleone D, Vasciaveo V, Franchino C, Rinaldi S, Tabaton M, Tamagno E. (2019)  Stroke and Amyloid-β Downregulate TREM-2 and Uch-L1 Expression that Synergistically Promote the Inflammatory Response. J Alzheimers Dis.71:907-920.

Naldi A, Provero P, Vercelli A, et al. Optic nerve sheath diameter asymmetry in healthy subjects and patients with intracranial hypertension [published online ahead of print, 2019 Oct 5]. Neurol Sci. 2019;10.1007/s10072-019-04076-y.

Roig-Puiggros S, Vigouroux RJ, Beckman D, Bocai NI, Chiou B, Davimes J, Gomez  G, Grassi S, Hoque A, Karikari TK, Kiffer F, Lopez M, Lunghi G, Mazengenya P, Meier S, Olguín-Albuerne M, Oliveira MM, Paraíso-Luna J, Pradhan J, Radiske A, Ramos-Hryb AB, Ribeiro MC, Schellino R, Selles MC, Singh S, Theotokis P, Chédotal A. Construction and reconstruction of brain circuits: normal and pathological axon guidance. J Neurochem. 2019 Oct 20. doi: 10.1111/jnc.14900. Review.

Schellino R, Boido M, Vercelli A. JNK signaling pathway involvement in spinal cord neuron development and death. Cells, Vol. 8, Pag 1576.

Zalfa C, Rota Nodari L, Vacchi E, Gelati M, Profico D, Boido M, Binda E, De Filippis L, Copetti M, Garlatti V, Daniele P, Rosati J, De Luca A, Pinos F, Cajola L, Visioli A, Mazzini L, Vercelli A, Svelto M, Vescovi AL, Ferrari D. Transplantation of clinical-grade human neural stem cells reduces neuroinflammation, prolongs survival and delays disease progression in the SOD1 rats. Cell Death Dis. 2019 Apr 25;10(5):345.

2018

Schellino R, Boido M, Borsello T, Vercelli A. Pharmacological c-Jun NH(2)-Terminal Kinase (JNK) Pathway Inhibition Reduces Severity of Spinal Muscular Atrophy Disease in Mice. Front Mol Neurosci. 2018 Sep 4;11:308. doi: 10.3389/fnmol.2018.00308.

Boido M, De Amicis E, Valsecchi V, Trevisan M, Ala U, Ruegg MA, Hettwer S, Vercelli A. Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy. Front Cell Neurosci. 2018 Jan 30;12:17. doi: 10.3389/fncel.2018.00017. eCollection 2018.

Zamboni V, Armentano M, Berto G, Ciraolo E, Ghigo A, Garzotto D, Umbach A, DiCunto F, Parmigiani E, Boido M, Vercelli A, El-Assawy N, Mauro A, Priano L, Ponzoni L, Murru L, Passafaro M, Hirsch E, Merlo GR. Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin000 dynamics. Sci Rep. 2018 8:7254.

Brancia C, Noli B, Boido M, Pilleri R, Boi A, Puddu R, Marrosu F, Vercelli A, Bongioanni P, Ferri GL, Cocco C. TLQP Peptides in Amyotrophic Lateral Sclerosis: Possible Blood Biomarkers with a Neuroprotective Role. Neuroscience. 2018 pii: S0306-4522(18)30214-8.

Burla R, La Torre M, Zanetti G, Bastianelli A, Merigliano C, Del Giudice S, Vercelli A, Di Cunto F, Boido M, Vernì F, Saggio I. p53-sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice. Frontiers in Genetics. 

Summers MJ, Rainero I, Vercelli AE, Aumayr G, de Rosario H, Mönter M, Kawashima R; My-AHA Consortium. The My Active and Healthy Aging (My-AHA) ICT platform to detect and prevent frailty in older adults: Randomized control trial design and protocol. Alzheimers Dement (N Y). 2018 4:252-262.

Piras A, Boido M. Autophagy inhibition: a new therapeutic target in spinal muscular atrophy. Neural Regen Res. 2018 May;13(5):813-814.

Tamagno E, Guglielmotto M, Monteleone D, Manassero G, Vasciaveo V, Tabaton M. The Unexpected Role of Aβ1-42 Monomers in the Pathogenesis of Alzheimer's Disease. J Alzheimers Dis. 2018;62(3):1241-1245.

Testa G, Staurenghi E, Giannelli S, Gargiulo S, Guglielmotto M, Tabaton M, Tamagno E, Gamba P, Leonarduzzi G. A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1. Redox Biol. 2018 17:423-431.

2017

Piras A, Schiaffino L, Boido M, Valsecchi V, Guglielmotto M, De Amicis E, Puyal J, Garcera A, Tamagno E, Soler RM, Vercelli A. Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy. Cell Death Dis. 2017 Dec 20;8(12):3223.

Ghibaudi M, Boido M, Vercelli A. Functional integration of complex miRNA networks in central and peripheral lesion and axonal regeneration.Prog Neurobiol. 2017 Aug 3. pii: S0301-0082(17)30012-6.

Faedo A, Laporta A, Segnali A, Galimberti M, Besusso D, Cesana E, Belloli S, Moresco RM, Tropiano M, Fucà E, Wild S, Bosio A, Vercelli AE, Biella G, Cattaneo E. Differentiation of human telencephalic progenitor cells into MSNs by inducible expression of Gsx2 and Ebf1. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1234-E1242.

Filippi M, Boido M, Terreno E. Imaging of MSC transplantation in neuroscience. Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14643.

Fucà E, Guglielmotto M, Boda E, Rossi F, Leto K, Buffo A. Preventive motor training but not progenitor grafting ameliorates cerebellar ataxia and deregulated autophagy in tambaleante mice. Neurobiol Dis. 2017 Feb 22.

Vercelli, A. Rainero, I., De Rosario, H., Summers, M., Wieching, R., Aumayr, G., Bandelow, S., Ciferri, L., Bazzani, M. (2017) My-active and healthy ageing (My-AHA): An ICT platform to detect frailty risk and propose intervention. SoftCOM Article number 8115505.

Vercelli A, Rainero I, Ciferri L., Boido, M, Pirri F. (2017) Robots in Elderly Care. Digitcult Special Issue.

Summers M, Madl T, Vercelli A., Aumayr G., Bleier DM, Ciferri L., Deep Machine Learning Application to the detection of Preclinical Neurodegenerative Diseases of Ageing. Digitcult Special Issue.

Manassero, G., Guglielmotto, M., Monteleone, D., Vasciaveo, V., Butenko, O., Tamagno, E., Arancio, O., Tabaton, M.. (2017). Dual Mechanism of Toxicity for Extracellular Injection of Tau Oligomers versus Monomers in Human Tau Mice. J Alzheimers Dis., 59(2):743-51.

Guglielmotto, M., Monteleone, D., Vasciaveo, V., Repetto, I.E., Manassero, G., Tabaton, M., Tamagno, E. (2017). The Decrease of Uch-L1 Activity Is a Common Mechanism Responsible for Aβ 42 Accumulation in Alzheimer's and Vascular Disease. Front Aging Neurosci., 9:320.

Tamagno, E., Guglielmotto, M., Monteleone, D., Manassero, G., Vasciaveo, V., Tabaton, M (2017). The Unexpected Role of Aβ1-42 Monomers in the Pathogenesis of Alzheimer's Disease. J Alzheimers Dis. 2017 Oct 30.

2016

Atassi N, Beghi E, Blanquer M, Boulis NM, Cantello R, Caponnetto C, Chiò A, Dunnett SB, Feldman EL, Vescovi A, Mazzini L; attendees of the International Workshop on Progress in Stem Cells Research for ALS/MND. Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials? Cytotherapy. 2016 Dec;18(12):1471-1475.

Brancia C, Noli B, Boido M, Boi A, Puddu R, Borghero G, Marrosu F, Bongioanni P, Orrù S, Manconi B, D'Amato F, Messana I, Vincenzoni F, Vercelli A, Ferri GL, Cocco C. VGF Protein and Its C-Terminal Derived Peptides in Amyotrophic Lateral Sclerosis: Human and Animal Model Studies. PLoS One. 2016 Oct 13;11(10):e0164689.

Repetto IE, Monti R, Tropiano M, Tomasi S, Arbini A, Andrade-Moraes CH, Lent R, Vercelli A. The Isotropic Fractionator as a Tool for Quantitative Analysis in Central Nervous System Diseases. Front Cell Neurosci. 2016 Aug 5;10:190.

Vercelli U, Diano M, Costa T, Nani A, Duca S, Geminiani G, Vercelli A, Cauda F. Node Detection Using High-Dimensional Fuzzy Parcellation Applied to the Insular Cortex. Neural Plast. 2016;2016:1938292.

Boido M, Vercelli A. Neuromuscular Junctions as Key Contributors and Therapeutic Targets in Spinal Muscular Atrophy. Front Neuroanat. 2016 Feb 3;10:6.

Mazzini L, Vescovi A, Cantello R, Gelati M, Vercelli A. Stem cells therapy for ALS. Expert Opin Biol Ther. 2016;16(2):187-99.

Filippi M, Boido M, Pasquino C, Garello F, Boffa C, Terreno E. Successful in vivo MRI tracking of MSCs labeled with Gadoteridol in a Spinal Cord Injury experimental model. Exp Neurol. 2016 Aug;282:66-77.

Pascente R, Frigerio F, Rizzi M, Porcu L, Boido M, Davids J, Zaben M, Tolomeo D, Filibian M, Gray WP, Vezzani A, Ravizza T. Cognitive deficits and brain myo-Inositol are early biomarkers of epileptogenesis in a rat model of epilepsy. Neurobiol Dis. 2016 Sep;93:146-55.

Manassero G, Guglielmotto M, Zamfir R, Borghi R, Colombo L, Salmona M, Perry G, Odetti P, Arancio O, Tamagno E, Tabaton M. Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein. Aging Cell. 2016 Oct;15(5):914-23.

Guglielmotto M, Reineri S, Iannello A, Ferrero G, Vanzan L, Miano V, Ricci L, Tamagno E, De Bortoli M, Cutrupi S. E2 Regulates Epigenetic Signature on Neuroglobin Enhancer-Promoter in Neuronal Cells. Front Cell Neurosci. 2016 Jun 1;10:147.

Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222.

2015

Queiroga C, Almeida A, Tomasi S, Vercelli A, Paula P, Vieira H. Unravelling carbon monoxide protection in cerebral ischemia: from the organelle to the organism. Springerplus. 2015 Jun 12;4(Suppl 1):L26.

Queiroga CS, Vercelli A, Vieira HL. Carbon monoxide and the CNS: challenges and achievements. Br J Pharmacol. 2015 Mar;172(6):1533-45.

Vercelli A, Biggi S, Sclip A, Repetto IE, Cimini S, Falleroni F, Tomasi S, Monti R, Tonna N, Morelli F, Grande V, Stravalaci M, Biasini E, Marin O, Bianco F, di Marino D, Borsello T. Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury. Cell Death Dis. 2015 Aug 13;6:e1854.

Valsecchi V, Boido M, De Amicis E, Piras A, Vercelli A. Expression of muscle-specific miRNA 206 in the progression of disease in a murine SMA model. PLoS One. 2015 Jun 1;10(6):e0128560.

Valenza M, Chen JY, Di Paolo E, Ruozi B, Belletti D, Ferrari Bardile C, Brilli E, Leoni V, Caccia C, Boido M, Vercelli A, Vandelli MA, Forni F, Cepeda C, Levine MS, Tosi G, Cattane E. Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington’s disease mice. EMBO Mol Med. 2015 Nov 20. pii: e201505413.