Sviluppo e patologia del cervello

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Gruppo guidato da Alessandro Vercelli

brain-development_vercelli

Pubblicazioni

2020

Boges D, Agus M, Sicat R, Magistretti PJ, Hadwiger M, C Calì (2020). Virtual reality framework for editing and exploring medial axis representations of nanometric scale neural structures. Computers & Graphics, June 24, 2020. DOI 10.1016/j.cag.2020.05.024

Stanga S, Caretto A, Boido M, Vercelli A. Mitochondrial Dysfunctions: A Red Thread across
Neurodegenerative Diseases. Int J Mol Sci. 2020 May 25;21(10):3719. doi: 10.3390/ijms21103719.

Besusso D*#, Schellino R#, Boido M, Belloli S, Parolisi R, Conforti P, Faedo A, Cernigoj M, Campus I, Laporta A, Dickinson Bocchi V, Murtaj V, Parmar M, Spaiardi P, Talpo F, Maniezzi C, Toselli MG, Biella G, Moresco RM, Vercelli A, Buffo A* and Cattaneo E*.(2020) Stem Cell-Derived Human Striatal Progenitors Innervate Striatal Targets and Alleviate Sensorimotor Deficit in a Rat Model of Huntington Disease. Stem Cell Reports. 2020 Apr 8. pii: S2213-6711(20)30108-9. doi:10.1016/j.stemcr.2020.03.018.
*corresponding authors; #co-first authors.

Boido M, Butenko O, Filippo C, Schellino R, Vrijbloed WV, Fariello RG, Vercelli A. A new protein curbs the hypertrophic effect of myostatin inhibition, adding remarkable endurance to motor performance in mice. PLoS One. 2020;15(3):e0228653. Published 2020 Mar 11. doi:10.1371/journal.pone.0228653

Valsecchi V*, Boido M*, Montarolo F, et al. The transcription factor Nurr1 is up-regulated in amyotrophic lateral sclerosis patients and SOD1-G93A mice [published online ahead of print, 2020 Mar 18]. Dis Model Mech. 2020;dmm.043513. doi:10.1242/dmm.043513 - *co-authors

2019

Boido M, Ghibaudi M, Gentile P, Favaro E, Fusaro R, Tonda-Turo C. Chitosan-based hydrogel to support the paracrine activity of mesenchymal stem cells in spinal cord injury treatment. Sci Rep. 2019 Apr 25;9(1):6402.         

Cofano F*, Boido M*, Monticelli M, Zenga F, Ducati A, Vercelli A, Garbossa D. Mesenchymal Stem Cells for Spinal Cord Injury: Current Options, Limitations, and Future of Cell Therapy. Int J Mol Sci. 2019 May 31;20(11). pii: E2698.

Crociara P, Chieppa MN, Vallino Costassa E, Berrone E, Gallo M, Lo Faro M, Pintore MD, Iulini B, D'Angelo A, Perona G, Botter A, Formicola D, Rainoldi A, Paulis M, Vezzoni P, Meli F, Peverali FA, Bendotti C, Trolese MC, Pasetto L, Bonetto V, Lazzari G, Duchi R, Perota A, Lagutina I, Quadalti C, Gennero MS, Dezzutto D, Desiato R, Boido M, Ghibaudi M, Valentini MC, Caramelli M, Galli C, Casalone C, Corona C. Motor neurondegeneration, severe myopathy and TDP-43 increase in a transgenicpig model of SOD1-linked familiar ALS. Neurobiol Dis 2019 Apr;124:263-275.

Guglielmotto M, Repetto IE, Monteleone D, Vasciaveo V, Franchino C, Rinaldi S, Tabaton M, Tamagno E. (2019)  Stroke and Amyloid-β Downregulate TREM-2 and Uch-L1 Expression that Synergistically Promote the Inflammatory Response. J Alzheimers Dis.71:907-920.

Naldi A, Provero P, Vercelli A, et al. Optic nerve sheath diameter asymmetry in healthy subjects and patients with intracranial hypertension [published online ahead of print, 2019 Oct 5]. Neurol Sci. 2019;10.1007/s10072-019-04076-y.

Roig-Puiggros S, Vigouroux RJ, Beckman D, Bocai NI, Chiou B, Davimes J, Gomez  G, Grassi S, Hoque A, Karikari TK, Kiffer F, Lopez M, Lunghi G, Mazengenya P, Meier S, Olguín-Albuerne M, Oliveira MM, Paraíso-Luna J, Pradhan J, Radiske A, Ramos-Hryb AB, Ribeiro MC, Schellino R, Selles MC, Singh S, Theotokis P, Chédotal A. Construction and reconstruction of brain circuits: normal and pathological axon guidance. J Neurochem. 2019 Oct 20. doi: 10.1111/jnc.14900. Review.

Schellino R, Boido M, Vercelli A. JNK signaling pathway involvement in spinal cord neuron development and death. Cells, Vol. 8, Pag 1576.

Zalfa C, Rota Nodari L, Vacchi E, Gelati M, Profico D, Boido M, Binda E, De Filippis L, Copetti M, Garlatti V, Daniele P, Rosati J, De Luca A, Pinos F, Cajola L, Visioli A, Mazzini L, Vercelli A, Svelto M, Vescovi AL, Ferrari D. Transplantation of clinical-grade human neural stem cells reduces neuroinflammation, prolongs survival and delays disease progression in the SOD1 rats. Cell Death Dis. 2019 Apr 25;10(5):345.

2018

Schellino R, Boido M, Borsello T, Vercelli A. Pharmacological c-Jun NH(2)-Terminal Kinase (JNK) Pathway Inhibition Reduces Severity of Spinal Muscular Atrophy Disease in Mice. Front Mol Neurosci. 2018 Sep 4;11:308. doi: 10.3389/fnmol.2018.00308.

Boido M, De Amicis E, Valsecchi V, Trevisan M, Ala U, Ruegg MA, Hettwer S, Vercelli A. Increasing Agrin Function Antagonizes Muscle Atrophy and Motor Impairment in Spinal Muscular Atrophy. Front Cell Neurosci. 2018 Jan 30;12:17. doi: 10.3389/fncel.2018.00017. eCollection 2018.

Zamboni V, Armentano M, Berto G, Ciraolo E, Ghigo A, Garzotto D, Umbach A, DiCunto F, Parmigiani E, Boido M, Vercelli A, El-Assawy N, Mauro A, Priano L, Ponzoni L, Murru L, Passafaro M, Hirsch E, Merlo GR. Hyperactivity of Rac1-GTPase pathway impairs neuritogenesis of cortical neurons by altering actin000 dynamics. Sci Rep. 2018 8:7254.

Brancia C, Noli B, Boido M, Pilleri R, Boi A, Puddu R, Marrosu F, Vercelli A, Bongioanni P, Ferri GL, Cocco C. TLQP Peptides in Amyotrophic Lateral Sclerosis: Possible Blood Biomarkers with a Neuroprotective Role. Neuroscience. 2018 pii: S0306-4522(18)30214-8.

Burla R, La Torre M, Zanetti G, Bastianelli A, Merigliano C, Del Giudice S, Vercelli A, Di Cunto F, Boido M, Vernì F, Saggio I. p53-sensitive epileptic behavior and inflammation in Ft1 hypomorphic mice. Frontiers in Genetics. 

Summers MJ, Rainero I, Vercelli AE, Aumayr G, de Rosario H, Mönter M, Kawashima R; My-AHA Consortium. The My Active and Healthy Aging (My-AHA) ICT platform to detect and prevent frailty in older adults: Randomized control trial design and protocol. Alzheimers Dement (N Y). 2018 4:252-262.

Piras A, Boido M. Autophagy inhibition: a new therapeutic target in spinal muscular atrophy. Neural Regen Res. 2018 May;13(5):813-814.

Tamagno E, Guglielmotto M, Monteleone D, Manassero G, Vasciaveo V, Tabaton M. The Unexpected Role of Aβ1-42 Monomers in the Pathogenesis of Alzheimer's Disease. J Alzheimers Dis. 2018;62(3):1241-1245.

Testa G, Staurenghi E, Giannelli S, Gargiulo S, Guglielmotto M, Tabaton M, Tamagno E, Gamba P, Leonarduzzi G. A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1. Redox Biol. 2018 17:423-431.

2017

Piras A, Schiaffino L, Boido M, Valsecchi V, Guglielmotto M, De Amicis E, Puyal J, Garcera A, Tamagno E, Soler RM, Vercelli A. Inhibition of autophagy delays motoneuron degeneration and extends lifespan in a mouse model of spinal muscular atrophy. Cell Death Dis. 2017 Dec 20;8(12):3223.

Ghibaudi M, Boido M, Vercelli A. Functional integration of complex miRNA networks in central and peripheral lesion and axonal regeneration.Prog Neurobiol. 2017 Aug 3. pii: S0301-0082(17)30012-6.

Faedo A, Laporta A, Segnali A, Galimberti M, Besusso D, Cesana E, Belloli S, Moresco RM, Tropiano M, Fucà E, Wild S, Bosio A, Vercelli AE, Biella G, Cattaneo E. Differentiation of human telencephalic progenitor cells into MSNs by inducible expression of Gsx2 and Ebf1. Proc Natl Acad Sci U S A. 2017 Feb 14;114(7):E1234-E1242.

Filippi M, Boido M, Terreno E. Imaging of MSC transplantation in neuroscience. Oncotarget. 2017 Jan 13. doi: 10.18632/oncotarget.14643.

Fucà E, Guglielmotto M, Boda E, Rossi F, Leto K, Buffo A. Preventive motor training but not progenitor grafting ameliorates cerebellar ataxia and deregulated autophagy in tambaleante mice. Neurobiol Dis. 2017 Feb 22.

2016

Atassi N, Beghi E, Blanquer M, Boulis NM, Cantello R, Caponnetto C, Chiò A, Dunnett SB, Feldman EL, Vescovi A, Mazzini L; attendees of the International Workshop on Progress in Stem Cells Research for ALS/MND. Intraspinal stem cell transplantation for amyotrophic lateral sclerosis: Ready for efficacy clinical trials? Cytotherapy. 2016 Dec;18(12):1471-1475.

Brancia C, Noli B, Boido M, Boi A, Puddu R, Borghero G, Marrosu F, Bongioanni P, Orrù S, Manconi B, D'Amato F, Messana I, Vincenzoni F, Vercelli A, Ferri GL, Cocco C. VGF Protein and Its C-Terminal Derived Peptides in Amyotrophic Lateral Sclerosis: Human and Animal Model Studies. PLoS One. 2016 Oct 13;11(10):e0164689.

Repetto IE, Monti R, Tropiano M, Tomasi S, Arbini A, Andrade-Moraes CH, Lent R, Vercelli A. The Isotropic Fractionator as a Tool for Quantitative Analysis in Central Nervous System Diseases. Front Cell Neurosci. 2016 Aug 5;10:190.

Vercelli U, Diano M, Costa T, Nani A, Duca S, Geminiani G, Vercelli A, Cauda F. Node Detection Using High-Dimensional Fuzzy Parcellation Applied to the Insular Cortex. Neural Plast. 2016;2016:1938292.

Boido M, Vercelli A. Neuromuscular Junctions as Key Contributors and Therapeutic Targets in Spinal Muscular Atrophy. Front Neuroanat. 2016 Feb 3;10:6.

Mazzini L, Vescovi A, Cantello R, Gelati M, Vercelli A. Stem cells therapy for ALS. Expert Opin Biol Ther. 2016;16(2):187-99.

Filippi M, Boido M, Pasquino C, Garello F, Boffa C, Terreno E. Successful in vivo MRI tracking of MSCs labeled with Gadoteridol in a Spinal Cord Injury experimental model. Exp Neurol. 2016 Aug;282:66-77.

Pascente R, Frigerio F, Rizzi M, Porcu L, Boido M, Davids J, Zaben M, Tolomeo D, Filibian M, Gray WP, Vezzani A, Ravizza T. Cognitive deficits and brain myo-Inositol are early biomarkers of epileptogenesis in a rat model of epilepsy. Neurobiol Dis. 2016 Sep;93:146-55.

Manassero G, Guglielmotto M, Zamfir R, Borghi R, Colombo L, Salmona M, Perry G, Odetti P, Arancio O, Tamagno E, Tabaton M. Beta-amyloid 1-42 monomers, but not oligomers, produce PHF-like conformation of Tau protein. Aging Cell. 2016 Oct;15(5):914-23.

Guglielmotto M, Reineri S, Iannello A, Ferrero G, Vanzan L, Miano V, Ricci L, Tamagno E, De Bortoli M, Cutrupi S. E2 Regulates Epigenetic Signature on Neuroglobin Enhancer-Promoter in Neuronal Cells. Front Cell Neurosci. 2016 Jun 1;10:147.

Klionsky DJ, Abdelmohsen K, Abe A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016;12(1):1-222.

2015

Queiroga C, Almeida A, Tomasi S, Vercelli A, Paula P, Vieira H. Unravelling carbon monoxide protection in cerebral ischemia: from the organelle to the organism. Springerplus. 2015 Jun 12;4(Suppl 1):L26.

Queiroga CS, Vercelli A, Vieira HL. Carbon monoxide and the CNS: challenges and achievements. Br J Pharmacol. 2015 Mar;172(6):1533-45.

Vercelli A, Biggi S, Sclip A, Repetto IE, Cimini S, Falleroni F, Tomasi S, Monti R, Tonna N, Morelli F, Grande V, Stravalaci M, Biasini E, Marin O, Bianco F, di Marino D, Borsello T. Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury. Cell Death Dis. 2015 Aug 13;6:e1854.

Valsecchi V, Boido M, De Amicis E, Piras A, Vercelli A. Expression of muscle-specific miRNA 206 in the progression of disease in a murine SMA model. PLoS One. 2015 Jun 1;10(6):e0128560.

Valenza M, Chen JY, Di Paolo E, Ruozi B, Belletti D, Ferrari Bardile C, Brilli E, Leoni V, Caccia C, Boido M, Vercelli A, Vandelli MA, Forni F, Cepeda C, Levine MS, Tosi G, Cattane E. Cholesterol-loaded nanoparticles ameliorate synaptic and cognitive function in Huntington’s disease mice. EMBO Mol Med. 2015 Nov 20. pii: e201505413.