28.10.2013 - G. Fisone, Karolinska Institute, Stockholm

Condividi su
Data dell'evento: 27/10/2013
gilberto_fisone_webb

Gilberto Fisone
Karolinska Institute, Stockholm
Gilberto Fisone (born in Vercelli, Italy) has been professor of Neuroscience at the Department of Neuroscience of the Karolinska Institute of Stockholm since 2006. PhD in Neurochemistry at Karolinska, postdoc at the Rockefeller University, New York (Greengard's lab).
Photo: Stefan Zimmerman

Motor and cognitive dysfunctions in Parkinson's disease: modelling and mechanisms
Parkinson's disease (PD) has been, until recently, mainly defined by the presence of characteristic motor symptoms, such as rigidity, tremor, bradykinesia/akinesia, and postural instability. Accordingly, pharmacological and surgical treatments have so far addressed these motor disturbances, leaving nonmotor, cognitive deficits an unmet clinical condition.
Unfortunately, deterioration of the executive functions, such as attention, recognition, working memory, and problem solving, often appear in an early, premotor phase of the disease and progressively increase in intensity, negatively affecting the quality of life of ?50%-60% of PD patients.
karolinska instAt present, the cellular mechanisms underlying cognitive impairments in PD patients are largely unknown and an adequate treatment is still missing. The preclinical research has recently developed new animal models that may open new perspectives for a more integrated approach to the treatment of both motor and cognitive symptoms of the disease.

karolinska_inst

Fisone and coworkers have identified abnormalities in signal transduction affecting distinct neuronal populations and underlying the severe motor complications, or dyskinesia, caused by prolonged administration of L-DOPA to parkinsonian patients.
More recently, they investigated the mechanisms at the basis of non-motor symptoms of PD, which include cognitive impairment and neuropsychiatric conditions, such as depression and anxiety.
Photo: Camilla Svensk

Ospite: Alessandro Vercelli

download pdf

Agenda

05 aprile 2024

NICO NeuroWebinar & Seminar

1 appointment per week, on Friday at 2.00 pm

Guarda il video

GiovedìScienza racconta la ricerca al NICO

Vivere per sempre. 
Una popolazione sempre più longeva, i suoi problemi e le risposte della ricerca

Hai perso la diretta? Guarda ora il video di GiovedìScienza al NICO: una puntata in diretta dai nostri laboratori dedicata alla ricerca sull'invecchiamento.

3 marzo 2022