Friday, 11th December - h 14:00
Seminars room, NICO
Neural connectivity networks of the mouse brain and their impairment in autism models
Functional Magnetic Resonance Imaging (MRI) has consistently highlighted altered functional connectivity across brain regions of autism spectrum disorder (ASD) patients. However, the expression and neural substrates of these alterations are highly heterogeneous and often conflicting. Moreover, their neurobiological underpinnings and etiopathological significance remain largely unknown.
Connectivity mapping in mouse models recapitulating mutations or developmental aberrations relevant for ASD can help reconcile these discrepant findings, and establish causal links between genes, developmental processes and connectional architecture. Recent research performed in my laboratory has demonstrated the feasibility of reliably mapping macroscale fMRI connectivity networks in the mouse brain, leading to the identification of several distributed systems that can be related to known networks of the human brain, including plausible mouse precursors of the human salience and default mode (DMN) networks1,2.
In my talk I will illustrate recently published and unpublished examples of the application of this approach to establish causal relationship between connectivity alterations and ASD-related mutations (e.g. CNTNAP2 o 16p11.2 microdeletion), neuro-developmental aberrations (e.g. callosal agenesis3) or impaired neuronal-microglia interactions4.
Collectively, our findings show that fMRI-based neural connectivity readouts in mouse ASD models can generate clinically-relevant neurobiological hypotheses, and begin to bring order to the “autism connectivity chaos”.
Host: Annalisa Buffo
1 F. Sforazzini et al., NeuroImage 87, 403 (2014)
2 A. Liska et al., Neuorimage (2015)
3 F. Sforazzini et al., Brain Struct Funct (2014)
4 Y. Zhan et al., Nat. Neurosci 17, 400 (2014)
I nostri giovani ricercatori aggiornano i colleghi sulle loro ricerche. Appuntamento ogni due venerdì in sala Seminari.
University of Turin, Italy
The Workshop is aimed at PhD students and young Postdocs with the goal to promote a thorough understanding of the functions of glial cells in health and disease. The program includes lectures on the newest conceptual advancements and methodological approaches in the study of glial cells in synaptic functions, development and CNS diseases.
Sportello LESIONI SPINALI
Una notizia che abbiamo letto tutti di recente sui giornali. Noi del NICO abbiamo la fortuna di collaborare da anni con il dott. Bruno Battiston e il prof. Diego Garbossa - i chirurghi che hanno svolto l'operazione - e ci siamo fatti spiegare bene in cosa consiste l’intervento, quale era la situazione del paziente e quali saranno i possibili risultati.
Tutto questo al di là delle semplificazioni e dei titoli roboanti dei giornali, comprensibilmente utilizzati per attirare l’attenzione dei lettori.