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Gruppo guidato da Carola Eva




Bertocchi I*, Cifarelli L, Oberto A, Eva C, Sprengel R, Mirza NR, Muglia P (2024). Radiprodil, a selective GluN2B negative allosteric modulator, rescues audiogenic seizures in mice carrying the GluN2A(N615S) mutation. Br J Pharmacol. 2024. IF: 9.473

Carretero-Guillén A, Treviño M, Gómez-Climent MA, Dogbevia GK, Bertocchi I, Sprengel R, Larkum ME, Vlachos A, Gruart A, Delgado-García JM &Hasan MT (2024). Dentate gyrus is needed for memory retrieval. Molecular Psychiatry. IF: 13.44


Bertocchi I*, Rocha-Almeida F, Romero-Barraga ́ MT, Cambiaghi M, Carretero-Guille ́ A, Botta P, Dogbevia GK, Trevino M, Mele P, Oberto A, Larkum ME, Gruart A, Sprengel R, Delgado-Garcıa JM* and Hasan MT* (2023). Pre- and postsynaptic N-methyl-D-aspartate receptors are required for sequential printing of fear memory engrams. iScience, Volume 26, Issue 11, 17 November 2023, 108050. IF: 5.8

Eltokhi A, Bertocchi I, Rozov A, Jensen V, Borchardt T, Taylor A, Proenca CC,1 Rawlins JNP, Bannerman DM* and Sprengel R* (2023). Distinct effects of AMPAR subunit depletion on spatial memory. Volume 26, Issue 11, 17 November 2023, 108116. IF: 5.8

Bertocchi I, Turroni S, Chiazza F* (2023). Editorial: Nutritional modulation of central nervous system development, maintenance, plasticity, and recovery. Front Neurosci. Nov 17; 17:1332191. doi: 10.3389/fnins.2023.1332191. IF: 5.15

Bertocchi I*, Cambiaghi M, Hasan MT (2023). Advances toward precision therapeutics for developmental and epileptic encephalopathies. Front Neurosci. 2023 Apr6;17:1140679. doi: 10.3389/fnins.2023.1140679. PMID: 37090807; PMCID: PMC10115946. IF: 5.15

Collotta D*, Bertocchi I(co-first), Chiapello E, Collino M (2023). Antisense oligonucleotides: a novel frontier in pharmacological strategy. Front. Pharmacol. 14:1304342. doi: 10.3389/fphar.2023.1304342. IF: 5.9


Anna Maria Nuzzo, Laura Moretti, Paolo Mele, Tullia Todros, Carola Eva, Alessandro Rolfo (2022) Effect of Placenta-Derived Mesenchymal Stromal Cells Conditioned Media on an LPS-Induced Mouse Model of Preeclampsia Int J Mol Sci. 2022 Jan 31;23(3):1674. doi: 10.3390/ijms23031674.

Oberto A, Bertocchi I, Longo A, Bonzano S, Paterlini S, Meda C, Della Torre S, Palanza P, Maggi A and Eva C (2022). Hypothalamic NPY-Y1R Interacts with Gonadal Hormones in Protecting Female Mice against Obesity and Neuroinflammation. Int J Mol Sci. 2022 Jun 6;23(11):6351. doi:10.3390/ijms23116351. PMID: 35683029; PMCID: PMC9180984

Alves GF, Stoppa I, Aimaretti E, Monge C, Mastrocola R, Porchietto E, Einaudi G, Collotta D, Bertocchi I, Boggio E, Gigliotti CL, Clemente N, Aragno M, Fernandes D, Cifani C, Thiemermann C, Dianzani C, Dianzani U and Collino M (2022). ICOS-Fc as innovative immunomodulatory approach to counteract inflammation and organ injury in sepsis. Front Immunol. 2022 Sep 2;13:992614. doi: 10.3389/fimmu.2022.992614. PMID: 36119089; PMCID: PMC9479331. IF: 7.561


Paterlini S, Panelli R, Gioiosa L, Parmigiani S, Franceschini P, Bertocchi I, Oberto A, Bartolomucci A, Eva C, Palanza P (2021). Conditional Inactivation of Limbic Neuropeptide Y-1 Receptors Increases Vulnerability to Diet-Induced Obesity in Male Mice. Int J Mol Sci. 2021 Aug 14;22(16):8745. doi: 10.3390/ijms22168745. PMID: 34445453; PMCID: PMC8395771. IF: 6.208

Bertocchi I, Eltokhi A, Rozov A, Nguyễn Chi V, Jensen V, Bus T, Pawlak V, Serafino M, Sonntag H, Yang B, Burnashev N, Li SB, Obenhaus HA, Both M, Niewoehner B, Single FN, Briese M, Boerner T, Gass P, Rawlins JNP, Köhr G, Bannerman DM& Sprengel R.(2021) Voltage-independent GluN2A-type NMDA receptor Ca2+ signaling promotes audiogenic seizures, attentional and cognitive deficits in mice. Commun Biol. Jan 8;4(1):59. doi: 10.1038/s42003-020-01538-4.


Bertocchi  I, Mele  P, Ferrero  G, Oberto  A, Carulli  D, Eva C (2020) NPY-Y1 receptor signaling controls spatial learning and perineuronal net expression. Neuropharmacology. Dec 4;184: doi:10.1016/j.neuropharm.2020.108425

Eva C, Oberto A, Longo A, Palanza P, Bertocchi I. (2020) Sex differences in behavioral and metabolic effects of gene inactivation: The neuropeptide Y and Y receptors in the brain. Neurosci Biobehav Rev. 2020 Oct 9. pii: S0149-7634(20)30577-7. doi: 10.1016/j.neubiorev.2020.09.020. [Epub ahead of print]

Ilaria Bertocchi, Alessandra Oberto, Angela Longo, Paola Palanza, Carola Eva (2020). Conditional inactivation of Npy1r gene in mice induces sex-related differences of metabolic and behavioral functions. Horm Behav 2020 Aug 13;125:104824. doi: 10.1016/j.yhbeh.2020.104824.

Bertocchi I, Foglietta F, Collotta D, Eva C, Brancaleone V, Thiemermann C, Collino M. (2020) The hidden role of NLRP3 inflammasome in obesity-related COVID-19 exacerbations: Lessons for drug repurposing. Br J Pharmacol. 177(21):4921-4930.

Mastrocola R, Collotta D, Gaudioso G, Le Berre M, Cento AS, Ferreira Alves G, Chiazza F, Verta R, Bertocchi I, Manig F, Hellwig M, Fava F, Cifani C, Aragno M, Henle T, Joshi L, Tuohy K, Collino M. (2020) Effects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inflammation. Nutrients. 12(9):2497.


Hasan MT. et al. Fear Memory Engram and its Plasticity in the Hypothalamic Oxytocin System. Neuron, DOI: 10.1016/j.neuron. 2019.04.029 (2019)

Acton D, Ren X, Di Costanzo S, Dalet A, Bourane S,  Bertocchi I, Eva C, Goulding M. Spinal NPY1R+ Neurons form an Essential Excitatory Pathway for Mechanical Itch. Cell Reports, Volume 28, Issue 3, 16 July 2019, Pages 625-639.e6


Longo A. et al. Conditional inactivation of Npy1r gene induces mice behavioural inflexibility and orbitofrontal cortex hyperactivity that are reversed by escitalopram. Neuropharmacology 2018 May 1;133:12-22. doi: 10.1016/j.neuropharm.2018.01.018. Epub 2018 Jan 17.


Rosario Statello et al. Reduced NPY Y1 receptor hippocampal expression and signs of decreased vagal modulation of heart rate in mice. PHYSIOLOGY & BEHAVIOR, vol. 172, p. 31-39, ISSN: 0031-9384, doi: 10.1016/j.physbeh.2016.07.017 (2017)

Nuzzo AM, Giuffrida D, Masturzo B, Mele P, Piccoli E, Eva C, Todros T, Rolfo A. (2017) Altered expression of G1/S phase cell cycle regulators in placental mesenchymal stromal cells derived from preeclamptic pregnancies with fetal-placental compromise. Cell Cycle. 16(2):200-212.


Mele P, Zammaretti F, Longo A, Panzica G, Oberto A, Eva C. (2016) Sex-dependent regulation of hypothalamic neuropeptide Y-Y1 receptor gene expression in leptin treated obese (ob/ob) or lean mice. Brain Res. 1649:102-9.

Bo E, Farinetti A, Marraudino M, Sterchele D, Eva C, Gotti S, Panzica G. (2016) Adult exposure to tributyltin affects hypothalamic neuropeptide Y, Y1 receptor distribution, and circulating leptin in mice. Andrology. 4(4):723-34.

Obenhaus HA, Rozov A, Bertocchi I, Tang W, Kirsch J, Betz H, Sprengel R. (2016). Causal Interrogation of Neuronal Networks and Behavior through Virally transduced Ivermectin Receptors. Front Mol Neurosci, 9:75


Longo A, Oberto A, Mele P, Mattiello L, Pisu MG, Palanza P, Serra M, Eva C. (2015) NPY-Y1 coexpressed with NPY-Y5 receptors modulate anxiety but not mild social stress response in mice. Genes Brain Behav. 14(7):534-42. doi: 10.1111/gbb.12232. Epub 2015 Aug 18.


Fontana R, Della Torre S, Meda C, Longo A, Eva C, Maggi A (2014). Estrogen replacement therapy regulation of energy metabolism in female mouse hypothalamus. Endocrinology, 155:2213-2221

Longo A, Mele P, Bertocchi I, Oberto A, Bachmann A, Bartolomucci A, Palanza P, Sprengel R, Eva C (2014). Conditional inactivation of Neuropeptide Y-Y1 receptors unravels the role of Y1 and Y5 receptors co-expressing neurons in anxiety. Biol Psych 76,840–849


Hasan MT. et al. Role of motor cortex NMDA receptors in learning-dependent synaptic plasticity of behaving mice. Nature Communications (2013). Article number: 2258 doi: 10.1038/ncomms3258 ISSN: 2041-1723