8-9 November :: Motor Neuron Diseases - III edition

Turin, Italy | 8-9 November 2024

III edition - hybrid workshop
MOTOR NEURON DISEASES:
UNDERSTANDING THE PATHOGENETIC MECHANISMS TO DEVELOP THERAPIES

REGISTRATION: from 2^nd to 22^nd of September 2024

VENUES
Palace of the Anatomical Institutes, C.so Massimo D’Azeglio 52, 10124, Torino, Italy

The upcoming meeting in numbers:
10 confirmed speakears
2 sessions of selected talks of participants
2 poster sessions
4 awards for the best presentations and posters
1 social dinner 

The meeting, organized within the NODES project, is in line with the research and innovation program ''Health Industry and Silver Economy'' (Spoke5), providing knowledge on innovative diagnostic/therapeutic strategies and regenerative medicine. 

Organizers: prof. Marina Boido & Serena Stanga

For info, contact: marina.boido@unito.it | serena.stanga@unito.it 

The third edition of the hybrid workshop will focus on:

• the most recent cellular and molecular mechanisms involved in the pathogenesis and progression of neuromuscular diseases (as ALS, SMA…) and, more in general, of pathologies characterized by muscular atrophy
• currently available treatments and new developing therapeutic strategies
• practical activities for advanced imaging methods and in silico analysis of muscle innervation

Topics & speakers

Session I - SMA disease mechanisms and therapeutic approaches

Melissa Bowerman, UK - Considering the importance of peripheral metabolic defects in the progression of neurodegenerative diseases: a focus on SMA
George Mentis, USA  - Sensory dysfunction as a major pathogenic event in mouse models and patients with spinal muscular atrophy
Piera Smeriglio, France - Epigenetic alterations in SMA

Session II - SMA: a look at the clinical research

Federica Ricci, Italy - The backward reasoning: inputs from SMA clinical practice
Marika Pane, Italy - The backward reasoning: inputs from SMA clinical evidence

Session III - ALS pathogenetic mechanisms

Eran Perlson, Israel - Unlocking ALS: Muscle Exosome Control TDP-43 Local Synthesis at the NMJ
Alain Prochiantz, France - From Parkinson Disease to Amyotrophic Lateral Sclerosis following the ENGRAILED-1 thread

Session IV - ALS heterogeneity and treatments 

Cristina Moglia, Italy - ALS phenotype heterogeneity: not only motor symptoms
Letizia Mazzini, Italy - Innovative treatments for ALS: current state and future directions

Closing Lecture 

Clive Svendsen, USA - Using iPSC technology and bioengineering to treat and model motor neuron diseases

supported by:

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Past editions
November 2022

The second edition (hybrid meeting) of the conference focused on Amyotrophic Lateral Sclerosis (ALS) and Spinal Muscular Atrophy (SMA), two severe neurological pathologies affecting motor neurons and causing their progressive degeneration.

November 2020 (virtual conference)

The first edition of the meeting registered more than 170 participants from Italy, France, Spain, Belgium, Norway, Brazil, Peru and Canada. The event has been a great occasion for keeping up-to-date with the latest advances in ALS and SMA field, and a good opportunity for networking and laying the foundations for future collaborations.