Amerigo Pagoto, Dep. of Molecular Biotechnology and Health Sciences, University of Turin

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Data dell'evento: 23/11/2018
seminars_2018

Friday, 23rd November – h 2:00 p.m.
Seminars Room, NICO

Amerigo Pagoto
PostDoc, Department of Molecular Biotechnology and Health Sciences, University of Turin

NEURO-PORTRAITS
Imaging applications in CNS diseases

One of the most effective ways to have clear in vivo information about brain pathological conditions is to visualize them. Nowadays, an array of imaging techniques is available and, thanks to their
intrinsic features, each of them is suitable for different applications.
MRI (Magnetic Resonance Imaging), characterized by a great spatial resolution and no limits in tissue penetration, allows to acquire highly resolved brain images without any interference by the
skull. However, one of the main drawbacks of the technique is the low sensitivity: a possible way to overcome the obstacle is to design highly sensitive (and specific) imaging probes. Following the
idea to target “readily available” vascular molecular proteins associated with neuroinflammation, anti-VCAM phospholipidic micelles containing Gd3+ (a positive contrast agent for MRI) were
developed.

Moreover, exploiting the same phospholipidic platform, anti-APOE micelles, able to bind amyloid plaques in AD (Alzheimer Diseases), were designed and tested.
OI (Optical Imaging), by contrast to MRI, is characterized by a very limited tissue penetration but is endowed with high sensitivity. Exploiting the technique it is possible, using an appropriate optical
probe, to localize even small lesions. Unfortunately, OI is suitable just for superficial applications, because the light is scattered and absorbed into the tissues. This is the reason why the optical
applications (and probes) are spreading out for surgical interventions, where the tissue is “visually available”.

Therefore, I will discuss about a project involving optical/surgical probes for the precise detection of glioblastoma multiforme.
During the seminar I will mainly give you an overview of the main neuro-applications I worked on during my Ph.D., together with a brief introduction to novel and ongoing projects.

Host: Silvia De Marchis

Agenda

21 giugno 2019

NICO Progress Report - INN Open Neuroscience Forum 2019

I nostri giovani ricercatori aggiornano i colleghi sulle loro ricerche. Appuntamento ogni due venerdì.

14 novembre 2019

BraYn 2019 - dal 14 al 16 novembre a Milano

Fino al 31 luglio è possibile sottomettere gli abstract per la seconda conferenza annuale dei giovani neuroscienziati, in programma a Milano dal 14 al 16 novembre 2019.

Ricerca

SCOPERTE NELL’IPOTALAMO LE TRACCE DELLA MEMORIA

Lo studio pubblicato su Neuron scalfisce il dogma che colloca principalmente nell’ippocampo la formazione dei ricordi. 
È possibile attivare o bloccare l’espressione della paura controllando selettivamente i neuroni ipotalamici che producono ossitocina. La scoperta di un team di ricerca europeo, rappresentato in Italia da noi del NICO – Università di Torino. Comprendere i circuiti nervosi che sottendono la memoria della paura può aiutare nel trattamento di disordini psichiatrici come l’ansia, in cui la paura si trasforma da risorsa per la sopravvivenza a fenomeno patologico.

10 giugno 2019