Elia Di Schiavi, CNR, Institute of Biosciences and BioResources, IBBR - Naples

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Data dell'evento: 20/11/2018
seminars_2018

Tuesday, 20th November – h 2:00 p.m.
Seminars Room, NICO

Elia Di Schiavi, PhD
Institute of Biosciences and BioResources, IBBR
Department of Biology, Agriculture and Food Science - CNR
Naples

Identification of neuroprotective molecules using a C. elegans model of Spinal Muscular Atrophy

Spinal muscular atrophy (SMA) is characterized by the progressive degeneration of motor neurons, leading to muscles atrophy, paralysis and patients death.
SMA is one of the most common genetic causes of infant mortality and is caused by disruption of Smn1. The mechanisms underlying motor neuron death are still elusive.

We propose the use of C.elegans as a model system to rapidly identify new genetic partners and complementary therapies.
The use of C.elegans provides a powerful and low cost system to directly assess the consequences of rescuing Smn1 loss at the organismal level, with many experimental advantages to rapidly devise effective drug discovery in a whole-animal and the unique feature to allow visualization of neurons in living animals.

Host: Alessandro Vercelli

Agenda

06 novembre 2018

ZEISS Academy Workshop – Microscopia Correlativa 3D

Le ultime novità nella Microscopia Correlativa Multi-modale. Registrazione obbligatoria.

16 febbraio 2019

Torino - 10th International Meeting STEROIDS and NERVOUS SYSTEM

Since 2001, this meeting represented an important event for basic and clinical researchers working on this emerging scientific topic. We will address state-of-the-art approaches in the field of steroids and nervous system, including behavior, epigenetics, genomic and non-genomic actions, the vitamin D, neurodegenerative and psychiatric disorders, and the interference among endocrine disruptors and steroid signaling.

Ricerca

Identificato un nuovo bersaglio per contrastare la SMA

L’inibizione della proteina JNK rallenta la progressione della malattia che colpisce i motoneuroni ed è la prima causa genetica di morte nell’infanzia. Lo dimostra uno studio pubblicato su Frontiers in Molecular Neuroscience dal nostro gruppo di ricerca guidato da Alessandro Vercelli, in collaborazione con l’Istituto Mario Negri di Milano. Chiarire i meccanismi molecolari alla base della SMA può aprire la strada allo sviluppo di nuove terapie.

24 ottobre 2018