Tuesday, 20th November – h 2:00 p.m.
Seminars Room, NICO
Identification of neuroprotective molecules using a C. elegans model of Spinal Muscular Atrophy
Spinal muscular atrophy (SMA) is characterized by the progressive degeneration of motor neurons, leading to muscles atrophy, paralysis and patients death.
SMA is one of the most common genetic causes of infant mortality and is caused by disruption of Smn1. The mechanisms underlying motor neuron death are still elusive.
We propose the use of C.elegans as a model system to rapidly identify new genetic partners and complementary therapies.
The use of C.elegans provides a powerful and low cost system to directly assess the consequences of rescuing Smn1 loss at the organismal level, with many experimental advantages to rapidly devise effective drug discovery in a whole-animal and the unique feature to allow visualization of neurons in living animals.
Host: Alessandro Vercelli
Since 2001, this meeting represented an important event for basic and clinical researchers working on this emerging scientific topic. We will address state-of-the-art approaches in the field of steroids and nervous system, including behavior, epigenetics, genomic and non-genomic actions, the vitamin D, neurodegenerative and psychiatric disorders, and the interference among endocrine disruptors and steroid signaling.
Un malfunzionamento dei mitocondri, le centrali energetiche delle cellule, causa lo sviluppo della SCA28, una forma ereditaria di atassia. Dopo 10 anni di studi e grazie al sostegno di Fondazione Telethon, la scoperta del team di ricerca guidato dai proff. Alfredo Brusco e Filippo Tempia dell’Università di Torino e NICO. Lo studio pubblicato sulla prestigiosa rivista Neurobiology of Disease.