Progress in Neurobiology, R, Melcangi e G. Panzica

Condividi su
01/02/2014
Progress in Neurobiology, R, Melcangi e G. Panzica
2014MelcangiProgNb-copertina

Progress in Neurobiology
Volume 113, February 2014, Pages 1–5 Special Issue

Special Issue
Allopregnanolone: State of the art  [link]

Roberto Cosimo Melcangi a
Gian Carlo Panzica b,c

Department of Pharmacological and Biomolecular Sciences, Section of Biomedicine and Endocrinology, 
Center of Excellence on Neurodegenerative Diseases, Università degli Studi di Milano

Department of Neuroscience, Università degli Studi di Torino
Neuroscience Institute Cavalieri Ottolenghi (NICO)

Allopregnanolone, a neuroactive steroid derived from progesterone, is synthesized within the nervous tissue, by means of specific enzymes. Contrary to progesterone and its first metabolite dihydroprogesterone, allopregnanolone is able to interact with GABA-A receptor and not with the classical progesterone receptor. This suggests that the effect of progesterone administration may be due to activation of progesterone receptor, or of GABA-A receptor, or both. However, this is rarely considered in the experimental studies.

Here we summarize and discuss the hot topics involving the actions of allopregnanolone within the nervous tissue. One major role of this neuroactive steroid is neuroprotection in case of lesion, ischemia or peripheral neuropathies (i.e., diabetes). In addition, allopregnanolone may reduce the symptoms of neurodegenerative diseases (e.g., Alzheimer, Parkinson, Niemann–Pick type C, multiple sclerosis) in animal models and now translational studies are developed for its therapeutic use. Allopregnanolone may exert a beneficial effect also in case of neuropathic pain and it is also a potential candidate for the treatment of mood and anxiety disorders.

Finally, this neuroactive steroid seems to have important physiological roles in the early differentiation of some neural circuits (in particular at hippocampal level), and to reduce stress during pregnancy. In conclusion, it appears that allopregnanolone is a key regulator of physiological functions and may have interesting therapeutic perspectives for neurodegenerative and psychiatric disorders.

Agenda

31 maggio 2019

NICO Progress Report - INN Open Neuroscience Forum 2019

I nostri giovani ricercatori aggiornano i colleghi sulle loro ricerche. Appuntamento ogni due venerdì.

Ricerca

Interferenti endocrini. Il Parlamento europeo impegna la Commissione a emanare norme più restrittive

Buone notizie da Bruxelles. Il Parlamento europeo ha approvato a larga maggioranza una risoluzione che impegna la Commissione (vecchia e nuova) a emanare entro giugno 2020 una normativa più restrittiva che disciplini cosmetici, giocattoli e imballaggi alimentari e che - finalmente - applichi agli EDCs le stesse cautele usate per i composti classificati come sospetti cangerogeni. Una tesi a lungo sostenuta dalla Endrocrine Society e fortemente osteggiata dai rappresentanti della industria chimica.

30 aprile 2019